The purpose of this study was to examine the stress of health-related majoring students on their physical and temporomandibular joint symptoms. The subjects were 283 college students in Chungcheongnam-do province from September 1 to November 30, 2012. The data were analyzed using SPSS 18.0(SPSS 18.0 K for window, SPSS Inc, USA) with the level of significance as 0.05. The findings of the study were as follows: There were significant differences among the university students in stress according to age, academic year, smoking and snack intake. Significant differences were found in digestive symptoms according to gender, academic year, drinking and snack intake, and there were significant differences in temporomandibular joint symptoms. Stress had a significant correlation to physical symptoms and temporomandibular joint symptoms. As for the influence of stress on physical symptoms and temporomanbular joint symptoms. In this study, how to help college students to relieve stress in a sound manner, to promote their physical, mental and oral health and ultimately to lead a sound college life should carefully be considered.