Postoperative treatment strategy and follow up management for breast cancer patients in Korea 21■ 본 논문은 2008년 임상종양학회 연구비 공모 과제로 선정되어 진행된 연구 결과입니다.after primary surgery and then annually exam. Mammogram, sonogram, bone scan were tend to consider essentially and PET CT, MRI were considered alternatively. CA15-3, CEA and some of blood chemistry were also essential orders in most responders.Conclusions : It seems that clinicians treating breast cancer in Korea showed some different trend with international guidelines. Therefore, a multicenter randomized trial is needed to confirm the different modality for follow up and our results could give an aid to design such study..

Adenomyoepithelioma is a biphasic neoplastic proliferation of luminal and myoepithelial cells. Patients are 22 to 92 years old, normally asymptomatic. It is either diagnosed as a palpable mass or as an occasional mammographic finding (1). Fine-needle aspiration cytology is the investigation of choice to diagnose (2) and immunohistochemistry is very useful in confirming the diagnosis (3). Adenomyoepithelioma is usually benign, although it may recur locally (4). Tubular variants and some lobular tumors with high mitotic activity or cytological atypia are particularly prone to local recurrence. Its treatment is complete local excision (5-7) and, in case of recurrence, a wider excision (5). Case Report: 47-year-old female with a breast mass on the external upper quadrant of the left breast. Ultrasound revealed an 8 millimeter homogeneous, well delimitated nodule with regular borders and medio-lateral mammography showed a well defined opaque mass with irregular borders. The anatomo-pathological and immunohistochemisty of the specimen from the needle core biopsy was inconclusive so an excisional biopsy was performed diagnosing a tubular adenomyoepithelioma. No additional treatment was performed with a follow-up of 20 months without recurrence. Review of published cases: 159 cases of adenomyoepithelioma almost all women mostly older than 45 years old. Adenomyoepithelioma is presented as a mass of on average 30 millimeters in either breast of lobular pattern most of the times. Adenomyoepithelioma demonstrated a borderline malignancy especially in women from 15 to 40 years of age or older than 80 years. Lobular pattern proved to be the most benign, while spindle pattern the most malignant variant and tubular pattern is the commonest one to recur. Low mitotic rates are associated with less recurrence or malignancy and high mitotic rates accompany adenomyoepitheliomas with great potential to metastasize. Conclusions: Adenomyoepithelioma affects women aged between 16 and 92 years in either breast. It may display a heterogeneous pattern and a borderline malignancy. Ultrasonographic images may play an important role as a first approach and fine-needle aspiration cytology combined with immunohistochemistry should define the diagnosis. Potential malignant adenomyoepitheliomas are associated with high mitotic activity, cytologic atypia (6) , necrosis and infiltrative borders (4). Metastases have only been documented in tumors 20 millimeter in diameter or larger (8) and distant metastases locations include lung, brain, jaw, soft tissues, thyroid, lymph nodes (mediastinal and axillary) and liver (6, 9-13) .