The objective of this study was to compare the compositions and immuno-enhancing effects of 6-year-old red ginseng powder (RGP) with those of its fractions. RGP was subjected to extraction with 100% ethanol to obtain an ethanol fraction (E) and residue 1 (R1). Then, R1 was subjected to extraction with distilled water to obtain water fraction (W) and residue 2 (R2). Chemical compositions were as follows: 4.94% acidic polysaccharides and 1.56% ginsenosides (amounts of Rg1, Re, Rf, Rg2, Rb1, Rc, Rd, and Rg3) in RGP, 0.11% acidic polysaccharides and 6.99% ginsenosides in E, 4.93% acidic polysaccharides and 0.40% ginsenosides in R1, 0.50% acidic polysaccharides and 0.30% ginsenosides in R2, and 7.46% acidic polysaccharides and 0.61% ginsenosides in W. Immuno-enhancing effects of fractions from RGP were examined based on suppression of immune responses by cyclophosphamide. In the first fraction test, the antibody response to SRBCs increased significantly in the R1-treated group, but not the E-treated group. In the second fraction test, W showed higher immuno-enhancing effect than R1 and R2. W, which contained the highest amount of acidic polysaccharides, restored numbers of T and B cells, macrophages, as well as CD4 + and CD8 + T cells in the spleen suppressed by cyclophosphamide. These results suggest that acidic polysaccharides from red ginseng may be more effective than saponin in enhancing immune functions and reducing immunotoxicity of cyclophosphamide.
Key words: Korea red ginseng, acidic polysaccharides, antibody forming cells, T cells, B cells
HTB (hybrid truss bridge) steel truss webs instead of concrete webs in prestressed box girder bridges has been widely used in, because of its structural benefit such as relatively less self-weight and good aesthetics due to open web structure. Since the core technology of this bridge is the connection system between concrete slabs and steel truss members, several connection systems were proposed and experimentally evaluated. Also, the selected joint system was applied to the real bride design and construction. The researches were performed on the connection system, since it can affect the global behavior of this bridge such as flexural and fatigue behaviors as well as the local behavior around the connection region. The evaluation study showned that HTB applied to a curved bridge or a eccentric loading bridge, characteristic has a weak torsional capacity compared to an ordinary PSC box girder bridges due to the open structure of HTB. In this study, three box shaped hybrid truss specimens were made and the torsional test and evaluation for them were performed in order to find out the torsional behavior of HTB according to the connection system.
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