Purpose:The purpose of the study is to examine the impact of job stress on the patient safety nursing activities among nurses. Methods: The subjects of the study are 258 nurses working at 15 small-medium sized hospitals in D city. Data analysis was done using frequency, percentage, average and standard deviation, t-test, one-way ANOVA, Scheffé test, Pearson's correlation coefficient, stepwise multiple regression. Results: The job stress scored average 3.67 and patient safety nursing activity scored average 4.35. Job stress was positively associated with patient safety nursing activity. It explains 9.49% of the variance. Conclusion: Universal and inevitable job stress among nurses should not exceed optimum level to assure patient safety. So, personal and organizational efforts to manage job stress are needed. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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