The purpose of this study was to investigate the factors that affect post-traumatic growth of general hospital nurses after they experience traumatic events. Methods: A cross-sectional correlation study design was used. Participants were 232 nurses from general hospitals in South Korea. Data, including self-report questionnaires, were collected from July 11th to 31st, 2019, and analyzed using descriptive statistics, t-test, One-way ANOVA, Scheffé test, Pearson's correlation coefficients and hierarchical multiple regression analysis in IBM SPSS Statistics 25.0. Results: Post-traumatic stress (r=.24, p<.001), resilience (r=.36, p<.001), and social support (r=.37, p<.001) for general hospital nurses had a positive correlation with post-traumatic growth. The factors that affected post-traumatic growth were a) sleep disturbance, emotional paralysis and dissociation symptom subcategory of post-traumatic stress (β=.34, p<.001) and b) persistence subcategory of resilience (β=.33, p<.001) and c) evaluation support subcategory of social support (β=.29, p<.001). Conclusion: Results indicate that it is necessary to develop and provide programs to nurses to improve post-traumatic stress management, strengthen their resilience and provide social support.