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A unified treatment of all currently available cumulant-based indexes of multivariate skewness and kurtosis is provided here, expressing them in terms of the third and fourth-order cumulant vectors respectively. Such a treatment helps reveal many subtle features and inter-connections among the existing indexes as well as some deficiencies, which are hitherto unknown. Computational formulae for obtaining these measures are provided for spherical and elliptically-symmetric, as well as skew-symmetric families of multivariate distributions, yielding several new results and a systematic exposition of many known results.