0.4. Solubilization of various blood group antigens by the detergent triton X-100

Dahr, Wolfgang; Kruger, Jéssica Henriques

doi:10.1016/0379-0738(83)90205-0

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“…The glycoprotein was also shown to have at least one free thiol group, and blocking of thiol groups inhibited the binding of some, but not all. antibodies to Fy" (Dahr & Kruger, 1983: Lisowska ~t ul, 1983. Hadley et al (1984) noticed that the Uuffy glycoprotein aggregated on SDS-PAGE after exposure to 2mercaptoethanol, suggesting the presence of disulphide bond(s) in the protein.…”

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Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fy^a/Fy^b antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a – b–) phenotype

et al. 1995

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The erythrocyte chemokine receptor, a receptor for Plasmodium vivax, carries the antigens of the Duffy blood group system. Sequence analysis of reticulocyte RNA from individuals of known Duffy phenotype showed that the Fya antigen differs from the Fyb antigen as a result of a single nucleotide difference (A131 or G) encoding amino acid Gly44 (Fya) or Asp (Fyb) in the N-terminal extracellular domain of the glycoprotein. Evidence is presented for two different genetic backgrounds giving rise to the Fy(a-b-) phenotype. The most likely genetic mechanism in most individuals of the Fy(a-b-) phenotype is down-regulation of Duffy glycoprotein mRNA. However, the Duffy gene from a very rare Caucasian individual (AZ) with the Fy(a-b-) phenotype has a 14 base-pair deletion (nucleotides 287-301) resulting in a frameshift which introduces a stop codon and produces a putative truncated 118 amino acid protein. The occurrence of this mutation in an apparently healthy individual raises questions about the functional importance of the Duffy glycoprotein not only in normal erythrocytes but also in all human cells and tissues.

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Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fy^a/Fy^b antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a – b–) phenotype

et al. 1995

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Indian Blood Group System and the An Wjantigen

2002

Human Blood Groups

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0.4. Solubilization of various blood group antigens by the detergent triton X-100

Cited by 2 publications

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Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fy^a/Fy^b antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a – b–) phenotype

Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fy^a/Fy^b antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a – b–) phenotype

Indian Blood Group System and the An Wjantigen

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0.4. Solubilization of various blood group antigens by the detergent triton X-100

Cited by 2 publications

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Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fya/Fyb antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a – b–) phenotype

Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fya/Fyb antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a – b–) phenotype

Indian Blood Group System and the An Wjantigen

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Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fy^a/Fy^b antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a – b–) phenotype

Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fy^a/Fy^b antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a – b–) phenotype