0015 PA-MSHA inhibits proliferation and induces apoptosis through the up-regulation and activation of caspases in the human breast cancer cell lines

Liu, Z.; Hou, Yilin; Dong, Ming; Di, Gen-Hong; Wu, Jianqiang; Shen, Zhaoyuan; Shao, Zi Yu

doi:10.1016/s0960-9776(09)70066-9

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“…Flow cytometry analysis revealed that PA-MSHA-induced cell cycle arrest in the G0/G1 phase prevented breast cancer cell multiplication. Additionally, amplified expression of cleaved caspase 3, 8, 9, and Fas protein indicated a higher rate of apoptosis in breast cancer cells treated with PA-MSHA in comparison to control [43]. In the next study, researchers investigated if PA-MSHA could reduce the growth of doxorubicinresistant breast cancer cells.…”

Section: Anti-tumor Potential Of Pa-msha: In Vitro Resultsmentioning

confidence: 99%

Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects

Bozic,

Živanović,

Živančević

et al. 2024

Cancers

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Cancer is a leading cause of death worldwide, for which finding the optimal therapy remains an ongoing challenge. Drug resistance, toxic side effects, and a lack of specificity pose significant difficulties in traditional cancer treatments, leading to suboptimal clinical outcomes and high mortality rates among cancer patients. The need for alternative therapies is crucial, especially for those resistant to conventional methods like chemotherapy and radiotherapy or for patients where surgery is not possible. Over the past decade, a novel approach known as bacteria-mediated cancer therapy has emerged, offering potential solutions to the limitations of conventional treatments. An increasing number of in vitro and in vivo studies suggest that the subtype of highly virulent Pseudomonas aeruginosa bacterium called Pseudomonas aeruginosa mannose-sensitive-hemagglutinin (PA-MSHA) can successfully inhibit the progression of various cancer types, such as breast, lung, and bladder cancer, as well as hepatocellular carcinoma. PA-MSHA inhibits the growth and proliferation of tumor cells and induces their apoptosis. Proposed mechanisms of action include cell-cycle arrest and activation of pro-apoptotic pathways regulated by caspase-9 and caspase-3. Moreover, clinical studies have shown that PA-MSHA improved the effectiveness of chemotherapy and promoted the activation of the immune response in cancer patients without causing severe side effects. Reported adverse reactions were fever, skin irritation, and pain, attributed to the overactivation of the immune response. This review aims to summarize the current knowledge obtained from in vitro, in vivo, and clinical studies available at PubMed, Google Scholar, and ClinicalTrials.gov regarding the use of PA-MSHA in cancer treatment in order to further elucidate its pharmacological and toxicological properties.

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Section: Anti-tumor Potential Of Pa-msha: In Vitro Resultsmentioning

confidence: 99%