0177 Occupational risk assessment on chrysotile production

Abstract

industries we conducted a nested case-control study matched on these factors. Analyses were performed with conditional logistic regression. Results The RR of overall sinonasal cancer (37 cases) was doubled in the upper exposure tertile compared to the lower exposure tertile. For adenocarcinomas (9 cases), the RR in the medium and upper exposure tertiles were 1.17 (95%CI 0.07-18.72) and 7.87 (95%CI 0.97-63.94), respectively. Comparable results were obtained from the case-control analysis indicating limited confounding by age, gender and wood dust exposure. No consistent trend was observed for squamous cell carcinomas. Conclusion Despite statistically non-significant results and limitations owing to the few cases, this study indicates increased risk of sinonasal adenocarcinomas among high level styrene exposed workers and could signal a carcinogenic effect of styrene.