industries we conducted a nested case-control study matched on these factors. Analyses were performed with conditional logistic regression. Results The RR of overall sinonasal cancer (37 cases) was doubled in the upper exposure tertile compared to the lower exposure tertile. For adenocarcinomas (9 cases), the RR in the medium and upper exposure tertiles were 1.17 (95%CI 0.07-18.72) and 7.87 (95%CI 0.97-63.94), respectively. Comparable results were obtained from the case-control analysis indicating limited confounding by age, gender and wood dust exposure. No consistent trend was observed for squamous cell carcinomas. Conclusion Despite statistically non-significant results and limitations owing to the few cases, this study indicates increased risk of sinonasal adenocarcinomas among high level styrene exposed workers and could signal a carcinogenic effect of styrene.

The development of the software complex as an information system of the monitoring and risk evaluation in an industrial plant was carried out as one of the innovative directions of the formation of scientific bases of the preventive environment which possess of capabilities to adapt to a particular enterprise and working conditions. The system includes both traditional methods of statistical analysis and methodologies for the adoption of management solutions for a professional risk, as well as innovative approaches as methods of logical-probabilistic analysis, with the adaptive mechanisms of the clarifying crucial rules based on the permanently updated database. This system is presented in a structured form as Software complex «Occupational risk-monitoring of the health of workers».

There were performed biochemical and cytological studies of blood in healthy workers of chrysotile asbestos plant in order to determine the functional state of the body, depending on the length of service and working conditions. Mentioned differences between the functional state of the organism were determined in the longitudinal study, under construction on schedule time series with the test group at specified intervals (every year for 7 years surveyed, the same group of healthy workers). The differences between the indices allow one to discriminate different levels of the functional state of the organism for the workers employed at processing complex with experience of 4 and 5 years, and for the employees in the mining and transport workshop with the experience of 5 and 6 years. As a result the work experience of 5 years is considered to be an occupational hazard for workers at processing complex, and 6 years of experience - as an occupational hazard for workers of mining and transport workshop.

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