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Whitley, Elise; Ball, Jonathan

doi:10.1186/cc1521

Cited by 505 publications

(214 citation statements)

References 7 publications

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“…Using our variability measurements (coefficient of variation = 20%) and a 2α = 0.05, an n = 9 gave us a power of 90% to detect a 30% difference in intimal area after carotid injury [21]. The data are expressed as the mean ± SEM.…”

Section: Methodsmentioning

confidence: 99%

Anti-Atherogenic Effect of Insulin in vivo

Kim

Chan²,

Dhaliwall³

et al. 2005

J Vasc Res

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Metabolic syndrome is a risk factor for atherosclerosis and restenosis. In metabolic syndrome, insulin resistance coexists with hyperinsulinemia and hyperlipidemia. Hyperlipidemia has growth-promoting effects, whereas insulin has both growth-promoting and growth-inhibitory effects on vascular smooth muscle cells in vitro. The objective of this study was to investigate the effects of hyperlipidemia and hyperinsulinemia on vascular cell growth in vivo after arterial injury. Rats fed a low-fat diet were treated with either subcutaneous blank (LFC) or insulin (LFI) implants. Rats fed a high-fat diet also received blank (HFC) or insulin (HFI) implants. After 3 days, rats received balloon carotid injury, and 14 days later they were sacrificed to measure neointimal area and proliferation. Hyperinsulinemia was present in LFI and HFI and hyperlipidemia was present in HFC and HFI. Neointimal area was higher in HFC (0.153 ± 0.009 mm², p < 0.05) but lower in LFI (0.098 ± 0.005, p < 0.01) than LFC (0.127 ± 0.005). In HFI (0.142 ± 0.008, p < 0.05) neointimal area was not different from HFC or LFC. In conclusion, insulin reduced neointimal growth, but the effect of insulin was diminished by the high-fat diet. Thus, our results demonstrate an anti-atherogenic effect of insulin in vivo and suggest that in metabolic syndrome insulin resistance rather than hyperinsulinemia is the atherogenic risk factor.

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Section: Methodsmentioning

confidence: 99%

Anti-Atherogenic Effect of Insulin in vivo

Kim

Chan²,

Dhaliwall³

et al. 2005

J Vasc Res

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“…Was estimated using Withley et al formula to compare proportions in case control study [14]. The power was set at 80%.…”

Section: Sample Sizementioning

confidence: 99%

Evaluation of Oxidative Status of Patients with Gout Attack in a Cameroonian Urban Hospital

Nkeck¹,

Singwé–Ngandeu²,

Moor³

et al. 2017

OJRA

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Background: Gout is the leading cause of microcrystalline arthritis worldwide and the most common cause of arthritis in adult men. The prevalence of cardiovascular disease, type II diabetes and metabolic syndrome is high among gout patients; one of the current hypotheses that may explain this relationship is based on oxidative stress; however, few studies have sought to investigate this relationship. Objective: The aim of this study was to determine the oxidative status of patients with gout attack. Methods: We conducted a case-control study over a 4 months period at the Rheumatology service of the Yaoundé Central Hospital. Cases were patients with an acute gout attack and controls were healthy subjects matched for sex and age. We evaluated uricemia, serum levels of Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase and Malondialdehyde (MDA). Oxidative stress was defined by an increase in MDA and/or a decrease in SOD, Catalase and GPx. Statistical analysis was performed by the S.P.S.S. 21.0 software. The Student's T-test was used to compare means; the significance threshold was 0.05. Results: Sixty subjects were recruited of which 30 with an acute gout attack and 30 healthy subjects. The mean ages of the cases and controls were respectively 58 ± 8 years and 57.6 ± 8 years. Uricemia was statistically higher in cases (81 ± 20 mg/L) compared to controls (47 ± 11 mg/L) (p < 0.001). MDA levels were higher among cases (1.37 ± 0.46 mmol/L) compared to controls (1.14 ± 0.39 mmol/L) (p < 0.05). There was no significant difference in serum levels of catalase, SOD and GPx between cases and controls. Conclusion: Patients with gout attack have an elevated serum level of malondialdehyde but their oxidative status seems similar to that of normal individuals.How to cite this paper: Nkeck, J.R., Singwé-Ngandeu, M., Moor, V.A., Chedjou,

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“…The sample size was calculated using Whitley's formula: N = 2 Cp, power/d 2 where N = sample size, Cp, power = constant defined by the values of p (threshold of significance) chosen available in the statistical tables [10]. For a value of α = 0.05 and a power of 95%, cp, power = 13.…”

Section: Sample Sizementioning

confidence: 99%

Effect of Therapeutic Group Education on Adherence and Blood Pressure Control among Uncontrolled Hypertensive Patients in Sub Saharan Africa

Nganou–Gnindjio¹,

Mfeukeu-Kuaté²,

Hamadou³

et al. 2018

WJCD

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Background: Hypertension is the leading cardiovascular risk factor worldwide, with the greatest burden in low-income settings. Blood pressure (BP) control is usually low resulting in high rates of uncontrolled patients and complications. Low awareness resulting in poor therapeutic adherence represents an important factor for insufficient blood pressure control in developing countries. Methods: This was a three months non-randomized control trial at the cardiology clinic of the Yaoundé Central Hospital. We included adults with essential and uncontrolled hypertension. The intervention consisted of group educative sessions every week focusing on knowledge of hypertension risk factors, complications, treatment, comorbidities, home self-monitoring of BP. Home blood pressure figures, drug compliance, and knowledge regarding hypertension were evaluated before and after. Results: 17 participants (8 women) with a mean age 56.2 ± 8.1 years. During intervention, mean SBP decreased by 30 mmHg while mean DBP drooped by 11 mmHg using home BP measures. Knowledge regarding hypertension, adherence and drug compliance increased by 36.5%, 88.2% and 81.4% respectively. Conclusion: Therapeutic group education resulted in a significant improvement in BP control amongst uncontrolled hypertensive patients in sub Saharan Africa.

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Untitled

Cited by 505 publications

References 7 publications

Anti-Atherogenic Effect of Insulin in vivo

Anti-Atherogenic Effect of Insulin in vivo

Evaluation of Oxidative Status of Patients with Gout Attack in a Cameroonian Urban Hospital

Effect of Therapeutic Group Education on Adherence and Blood Pressure Control among Uncontrolled Hypertensive Patients in Sub Saharan Africa

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