1,2,3- and 1,2,4-Oxadiazoles

Clapp, Leallyn B.

doi:10.1016/b978-008096519-2.00089-8

Cited by 33 publications

(20 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,2,4 Oxadiazoles are well known compounds which exhibit diversified biological activities [1][2][3][4]. The work from our laboratory also cites other pharmacological properties previously reported by other researchers [5,6].…”

Section: Introductionsupporting

confidence: 64%

A Handy and Solventless Direct Route to Primary 3-[3-Aryl)-1,2,4-oxadiazol-5-yl]propionamides Using Microwave Irradiation

Filho

2006

Molecules

View full text Add to dashboard Cite

show abstract

Section: Introductionsupporting

confidence: 64%

A Handy and Solventless Direct Route to Primary 3-[3-Aryl)-1,2,4-oxadiazol-5-yl]propionamides Using Microwave Irradiation

Filho

2006

Molecules

View full text Add to dashboard Cite

show abstract

“…The various literature survey were reported that 1, 3, 4-oxadiazoles a class of five member heterocyclic compounds possessed a wide range of biological activities such as antimicrobial 3 , antiinflammatory 4 , antifungal 5 , anticonvulsant 6 , anthelmintics 7 , analgesic 8 , insecticidal 9 , local anesthetic 10 , antidiarrheal 1 , anticancer 12 , hypoglycaemic 13 , protease inhibitor-resistant HIV-1 14 , vasorelaxant 15 etc.…”

Section: 3 4-oxadiazolementioning

confidence: 99%

Untitled

2017

IJPSR

View full text Add to dashboard Cite

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases and improper immune development. The main objective of the present research work was the synthesis of N-(4-{[5-(substituted phenyl)-1,3,4-oxadiazol-2-yl] methoxy}phenyl) acetamide derivatives and to evaluate the hepatocytes regenerator potentiality by molecular docking with 2V2T-NF-KB and as well as In vivo methods and the synthesized compounds were characterized by IR, NMR, and Mass spectroscopy. The in-vivo Hepatoprotective activity was carried out by using albino rats where CCl 4 was used as a hepatotoxin. Molecular docking is performed to find out the binding affinity or molecular interaction energy (kcal/mol) of docked compounds. In silico molecular docking studies displayed the binding energies: -5

show abstract

“…Oxadiazoles have often been described as bio-isosteres for amides and esters [4]. Due to increased hydrolytic [5] and metabolic stabilities of the oxadiazole ring, improved pharmacokinetic and in vivo performance is often observed, which make these heterocycles to an important structural motif for the pharmaceutical industry [6]. Single molecules in the crystal structure of the title compound are linked by C-H···Nhydrogen bonds:…”

Section: Source Of Materialsmentioning

confidence: 99%