1-(2-Deoxy-D-glucopyranosyl)-5-fluorocytosine¹

Performance of revised STO(1M)‐3G basis set for prediction of 5‐fluorocytosine chemical shifts

“…In our current study, we decided to verify the performance of recently redesigned STO(1M)‐3G basis sets for prediction of nuclear shieldings and chemical shifts of an important antifungal drug and anticancer prodrug—5‐fluorocytosine (5FC) …”

“…5FC belongs to the group of the fluorinated pyrimidine analogues. It was used for the first time in 1968 in the treatment of systemic fungal infections . Nowadays, it is widely used in combination with amphotericin B in the treatment of serious infections caused by Candida (septicemia and endocarditis) and Cryptococcus (meningitis and pulmonary infections) .…”

Carcinogenic Activity of 2-N,N-Dimethylamino-5-phenylazopyridine1

“…The product, 1.92 g. (96%), carefully protected from atmospheric moisture, was dried in vacua at 80°over P»06; ^ 1 2.93 (NH), 3.6-4.0 and 6.21 (Nils'9, 6.35 and 6.92 µ (CO, •, Anal. Cak'd, for Cu,H]3Cl2N3O2-0.25H2O: C, 51.7; H, 5.66; Cl.…”

“…210-212°: [ ]29> +10°(1% in 1 HCI); %; 2.80, 2.95, and 3.1 (NH, NH. ), 3.05, 3.81, 6.12, and 6.50 (NH* %), 6.27 and 7.12 µ (CO*™). Experimental Mills Reaction with 2-Dimethylamino-5-aminopyridine.-2-Dimethylamino-5-nitropyridine6 was reduced in a Parr apparatus with 5% palladium on carbon in 95% ethanol.…”

“…All azo compounds were fed at the 0.06 level. 6 Commonly called Butter yellow'. a great deal of attention as an antimetabolite in the treatment of cancer.3 Thus, it was desirable to prepare several derivatives of 5-fluoropyrimidine.…”