1,25‐Dihydroxyvitamin D<sub>3</sub> Regulates the Synthesis of γ‐Glutamyl Transpeptidase and Glutathione Levels in Rat Primary Astrocytes

Garcion, Emmanuel; Sindji, Laurence; Leblondel, G.; Brachet, Philippe; Darcy, F.

doi:10.1046/j.1471-4159.1999.0730859.x

Cited by 208 publications

(150 citation statements)

References 68 publications

(72 reference statements)

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“…41 1,25-VD enhanced intracellular GSH pools, and thus decreased free radical formation in rat primary astrocytes. 42 Furthermore, vitamin D has also been reported to reduce oxidative stress by upregulating antioxidant systems, including GSH, GPx and superoxide dismutase in rats. 43 The results from these studies suggested that vitamin D participated in antioxidant machinery and protected cells from oxidative challenge.…”

Section: Discussionmentioning

confidence: 99%

Protective role of 1α, 25‐dihydroxyvitamin D₃ against oxidative stress in nonmalignant human prostate epithelial cells

Bao

Ting

Hsu

et al. 2008

Intl Journal of Cancer

146

108

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Overproduction of reactive oxygen species (ROS), through either endogenous or exogenous sources, could induce DNA damage, and accumulation of DNA damage might lead to multistep carcinogenesis. The antioxidative effects of vitamin D have been suggested by epidemiological and many in vitro and in vivo laboratory studies. While exploring the antioxidative effects of vitamin D in prostate cells, we found that the active form of vitamin D, 1a, 25-dihydroxyvitamin D 3 (1,25-VD), can protect nonmalignant human prostate epithelial cell lines, BPH-1 and RWPE-1, but not malignant human prostate epithelial cells, CWR22R and DU 145, from oxidative stress-induced cell death. Glucose-6-phosphate dehydrogenase (G6PD), a key antioxidant enzyme, was dose-and time-dependently induced by 1,25-VD. Mechanistic studies using chromatin immunoprecipitation (ChIP) assay revealed that a direct repeat-3 (DR3) vitamin D response element located in the first intron of the G6PD genome can be bound by liganded vitamin D receptor, thereby regulating G6PD gene expression. Increasing G6PD activity and glutathione level by 1,25-VD can scavenge cellular ROS. Moreover, the protective effects of 1,25-VD were abolished by dehydroepiandrosterone, a noncompetitive inhibitor of G6PD activity. Together, our results showed that 1,25-VD can protect nonmalignant prostate cells from oxidative stress-induced cell death by elimination of ROS-induced cellular injuries through transcriptional activation of G6PD activity. The antioxidative effect of vitamin D strengthens its roles in cancer chemoprevention and adds to a growing list of beneficial effects of vitamin D against cancer.

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Section: Discussionmentioning

confidence: 99%

Protective role of 1α, 25‐dihydroxyvitamin D₃ against oxidative stress in nonmalignant human prostate epithelial cells

Bao

Ting

Hsu

et al. 2008

Intl Journal of Cancer

146

108

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“…Vitamin D might show its neuroprotective effect also by controlling brain detoxification processes (Wiseman 1993;Garcion et al 1997Garcion et al , 1999Wang et al 2001;Garcion et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Association between Vitamin D Receptor Gene Polymorphism and Alzheimer's Disease

Gezen-Ak

Dursun

Ertan

et al. 2007

Tohoku J. Exp. Med.

138

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Vitamin D 3 is known to be involved in neuroprotection and exert its neuroprotective effects by modulating neuronal calcium homeostasis and production of neurotrophins. The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D 3 to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitamin D-mediated pathways. In this study, our aim was to determine whether there is an association between VDR gene and lateonset Alzheimer's disease (AD) in order to see if vitamin D contributes to AD or not. One hundred and four cases of dementia of Alzheimer type and 109 age-matched controls were genotyped according to ApaI (a: + restriction site and A: no restriction site) and TaqI (t: + restriction site and T: no restriction site) sites in intron 8 and exon 9 of the ligand-binding site of VDR gene. When the controls and patients were compared for their ApaI genotypes, the frequency of the patients with Aa genotype was significantly higher than the frequency of the healthy individuals with the same genotype ( p = 0.008, χ 2 = 9.577, OR = 2.30). Thus, the "Aa" genotype may increase the risk of developing AD 2.3 times when compared with the "AA" genotype. On the other hand, the "AT" haplotype was significantly higher in controls ( p = 0.006) indicating a protective role of the "AT" haplotype in AD. Consequently, this study provides evidence for a possible link between AD and vitamin D. vitamin D; VDR; Alzheimer's disease; SNP; haplotype © 2007 Tohoku University Medical PressThe most common form of degenerative dementia is Alzheimer's disease (AD) constituting approximately 60-70% of cases (Emilien et al. 2004). It is a chronic, degenerative, dementing illness with typically insidious onset (Rocca et al. 1991). The key aims in therapeutic strategies of AD are to decrease the neuronal damage, provide maintenance or regeneration of neu r o n s

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“…During transient ischemic events, transforming growth factor and GDNF are upregulated in hippocampal cells to promote survival (Garcion, Sindji et al 1999). As discussed earlier, vitamin D augments innate antioxidative defenses by increasing glutathione and GDNF concentrations (Wion, MacGrogan et al 1991;Naveilhan, Neveu et al 1996).…”

Section: Vitamin D Cerebrovascular Disease and Vascular Dementiamentioning

confidence: 92%

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Buell

Dawson‐Hughes

2008

Molecular Aspects of Medicine

310

222

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1,25‐Dihydroxyvitamin D₃ Regulates the Synthesis of γ‐Glutamyl Transpeptidase and Glutathione Levels in Rat Primary Astrocytes

Cited by 208 publications

References 68 publications

Protective role of 1α, 25‐dihydroxyvitamin D₃ against oxidative stress in nonmalignant human prostate epithelial cells

Protective role of 1α, 25‐dihydroxyvitamin D₃ against oxidative stress in nonmalignant human prostate epithelial cells

Association between Vitamin D Receptor Gene Polymorphism and Alzheimer's Disease

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

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1,25‐Dihydroxyvitamin D3 Regulates the Synthesis of γ‐Glutamyl Transpeptidase and Glutathione Levels in Rat Primary Astrocytes

Cited by 208 publications

References 68 publications

Protective role of 1α, 25‐dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells

Protective role of 1α, 25‐dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells

Association between Vitamin D Receptor Gene Polymorphism and Alzheimer's Disease

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Contact Info

Product

Resources

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1,25‐Dihydroxyvitamin D₃ Regulates the Synthesis of γ‐Glutamyl Transpeptidase and Glutathione Levels in Rat Primary Astrocytes

Protective role of 1α, 25‐dihydroxyvitamin D₃ against oxidative stress in nonmalignant human prostate epithelial cells

Protective role of 1α, 25‐dihydroxyvitamin D₃ against oxidative stress in nonmalignant human prostate epithelial cells