1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis

Garcion, Emmanuel; Nataf, Serge; Bérod, Anne; Darcy, F.; Brachet, Philippe

doi:10.1016/s0169-328x(96)00260-4

Cited by 188 publications

(125 citation statements)

References 49 publications

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“…Vitamin D might show its neuroprotective effect also by controlling brain detoxification processes (Wiseman 1993;Garcion et al 1997Garcion et al , 1999Wang et al 2001;Garcion et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Association between Vitamin D Receptor Gene Polymorphism and Alzheimer's Disease

Gezen-Ak

Dursun

Ertan

et al. 2007

Tohoku J. Exp. Med.

138

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Vitamin D 3 is known to be involved in neuroprotection and exert its neuroprotective effects by modulating neuronal calcium homeostasis and production of neurotrophins. The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D 3 to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitamin D-mediated pathways. In this study, our aim was to determine whether there is an association between VDR gene and lateonset Alzheimer's disease (AD) in order to see if vitamin D contributes to AD or not. One hundred and four cases of dementia of Alzheimer type and 109 age-matched controls were genotyped according to ApaI (a: + restriction site and A: no restriction site) and TaqI (t: + restriction site and T: no restriction site) sites in intron 8 and exon 9 of the ligand-binding site of VDR gene. When the controls and patients were compared for their ApaI genotypes, the frequency of the patients with Aa genotype was significantly higher than the frequency of the healthy individuals with the same genotype ( p = 0.008, χ 2 = 9.577, OR = 2.30). Thus, the "Aa" genotype may increase the risk of developing AD 2.3 times when compared with the "AA" genotype. On the other hand, the "AT" haplotype was significantly higher in controls ( p = 0.006) indicating a protective role of the "AT" haplotype in AD. Consequently, this study provides evidence for a possible link between AD and vitamin D. vitamin D; VDR; Alzheimer's disease; SNP; haplotype © 2007 Tohoku University Medical PressThe most common form of degenerative dementia is Alzheimer's disease (AD) constituting approximately 60-70% of cases (Emilien et al. 2004). It is a chronic, degenerative, dementing illness with typically insidious onset (Rocca et al. 1991). The key aims in therapeutic strategies of AD are to decrease the neuronal damage, provide maintenance or regeneration of neu r o n s

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“…Vitamin D might show its neuroprotective effect also by controlling brain detoxification processes (Wiseman 1993;Garcion et al 1997Garcion et al , 1999Wang et al 2001;Garcion et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Association between Vitamin D Receptor Gene Polymorphism and Alzheimer's Disease

Gezen-Ak

Dursun

Ertan

et al. 2007

Tohoku J. Exp. Med.

138

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“…Studies have shown that vitamin D may protect the structure and integrity of neurons through detoxification pathways and neurotrophin synthesis Kang and Schuman 2000). Similar to the benefits of traditional antioxidant nutrients, 1, 25(OH) 2 D 3 inhibits inducible nitric oxide synthase (iNOS) (Garcion, Nataf et al 1997), an enzyme that is upregulated during ischemic events, and in patients with Alzheimer's and Parkinson's disease. 1, 25(OH) 2 D 3 also enhances innate antioxidant pathways.…”

Section: 25(oh) 2 D 3 and Neuronal Protectionmentioning

confidence: 99%

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Buell

Dawson‐Hughes

2008

Molecular Aspects of Medicine

310

222

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“…[66,67] Others schizophrenia, respiratory infection, all-cause mortality, etc. [18,19] by vitamin D via downregulation of inducible nitric oxide synthase (iNOS) expression [31] . Vitamin D plays a role in regulating T and B cell functions.…”

Section: Functionsmentioning

confidence: 99%

Role of vitamin D in immune responses and autoimmune diseases, with emphasis on its role in multiple sclerosis

Zhang

2010

Neurosci. Bull.

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1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis

Cited by 188 publications

References 49 publications

Association between Vitamin D Receptor Gene Polymorphism and Alzheimer's Disease

Association between Vitamin D Receptor Gene Polymorphism and Alzheimer's Disease

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Role of vitamin D in immune responses and autoimmune diseases, with emphasis on its role in multiple sclerosis

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