1,25-Dihydroxyvitamin D3 Suppresses Telomerase Expression and Human Cancer Growth through MicroRNA-498

Kasiappan, Ravi; Shen, Zheng; Tse, Anfernee Kai-Wing; Jinwal, Umesh K.; Tang, Joseph; Lungchukiet, Panida; Sun, Yinyan; Kruk, Patricia A.; Nicosia, Santo V.; Zhang, Xiaohong; Bai, Wenlong

doi:10.1074/jbc.m112.407189

Cited by 113 publications

(90 citation statements)

References 57 publications

(42 reference statements)

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“…Consistent with these observations a recent experimental investigation has shown that, in ovarian tumor and ovarian cancer cell lines, microRNA-498 (miR-498) induced by 1,25OH 2 D 3 decreased hTERT mRNA expression, fostered cell death, and suppressed tumor growth (Kasiappan et al, 2012). Conversely, the ability of 1,25OH 2 D 3 to decrease hTERT mRNA and to suppress ovarian cancer growth was compromised in the absence of miR-498, following its depletion in cell lines and in tumor-bearing mice (Kasiappan et al, 2012). Finally, Vit D has been reported to foster several types of malignant cells to undergo differentiation toward more mature phenotypes or to induce cell death by triggering apoptosis according to the cell type (Gocek & Studzinski, 2009).…”

Section: Effects Of Vitamin D On Tumor Progressionsupporting

confidence: 59%

“…On the contrary, VDR overexpression resulted in a potentiation of cell growth arrest (Hedlund et al, 1996;Welsh, 2012;Zhuang et al, 1997). Interestingly, recent studies have shown that 1,25(OH) 2 D 3 may also affect ovarian cancer cells proliferation by decreasing human telomerase reverse transcriptase (hTERT) mRNA through a small non-coding RNA (Ikeda et al, 2003;Kasiappan et al, 2012). Consistent with these observations a recent experimental investigation has shown that, in ovarian tumor and ovarian cancer cell lines, microRNA-498 (miR-498) induced by 1,25OH 2 D 3 decreased hTERT mRNA expression, fostered cell death, and suppressed tumor growth (Kasiappan et al, 2012).…”

Section: Effects Of Vitamin D On Tumor Progressionmentioning

confidence: 99%

“…Interestingly, recent studies have shown that 1,25(OH) 2 D 3 may also affect ovarian cancer cells proliferation by decreasing human telomerase reverse transcriptase (hTERT) mRNA through a small non-coding RNA (Ikeda et al, 2003;Kasiappan et al, 2012). Consistent with these observations a recent experimental investigation has shown that, in ovarian tumor and ovarian cancer cell lines, microRNA-498 (miR-498) induced by 1,25OH 2 D 3 decreased hTERT mRNA expression, fostered cell death, and suppressed tumor growth (Kasiappan et al, 2012). Conversely, the ability of 1,25OH 2 D 3 to decrease hTERT mRNA and to suppress ovarian cancer growth was compromised in the absence of miR-498, following its depletion in cell lines and in tumor-bearing mice (Kasiappan et al, 2012).…”

Section: Effects Of Vitamin D On Tumor Progressionmentioning

confidence: 99%

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Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy. Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. Results and conclusion: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.

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Section: Effects Of Vitamin D On Tumor Progressionsupporting

confidence: 59%

Section: Effects Of Vitamin D On Tumor Progressionmentioning

confidence: 99%

Section: Effects Of Vitamin D On Tumor Progressionmentioning

confidence: 99%

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Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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“…The antitumor activity of 1,25(OH) 2 D 3 can be mediated by microRNA specific for the telomerase transcript in OC and in other human cancer types (29). It has been demonstrated that 1,25(OH) 2 D 3 also inhibits proliferation of adrenocortical and pancreatic cancer cells and suppresses hepatocellular carcinoma development by reducing inflammatory cytokine production in vivo (30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Polymorphic variants in the vitamin D pathway genes and the risk of ovarian cancer among non-carriers of BRCA1/BRCA2 mutations

et al. 2015

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Abstract. Previous studies have produced inconsistent results regarding the contribution of single-nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene to ovarian cancer (OC) in various ethnicities. Additionally, little has been established with regard to the role of SNPs located in the retinoid X receptor α (RXRA), vitamin D-binding protein [also know as group-specific component (GC)] and VDR genes in non-carriers of the breast cancer 1/2 early onset (BRCA1/BRCA2) gene mutations. All participating individuals in the present study were evaluated for BRCA1 mutations (5382incC, C61G and 4153delA) with HybProbe assays, and for BRCA2 mutation (5946delT) using high-resolution melting (HRM) analysis. The associations of 8 SNPs located in RXRA, GC and VDR were investigated in OC patients without the BRCA1/BRCA2 mutations (n=245) and healthy controls (n=465). Genotyping of RXRA rs10881578 and rs10776909, and GC rs1155563 and rs2298849 SNPs was conducted by HRM analysis, while RXRA rs749759, GC rs7041, VDR BsmI rs1544410 and FokI rs2228570 genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism analysis. In addition, the gene-gene interactions among all tested SNPs were studied using the epistasis option in PLINK software. The lowest P-values of the trend test were identified for VDR rs1544410 and GC rs2298849 as P trend =0.012 and P trend =0.029, respectively. It was also found that, in the dominant inheritance model, VDR BsmI contributed to an increased risk of OC [odds ratio (OR), 1.570; 95% confidence interval (CI), 1.136-2.171; P=0.006; P corr =0.048]. The gene-gene interaction analysis indicated a significant interaction between RXRA rs749759 and VDR FokI rs2228570 (OR for interaction, 1.687; χ 2 =8.278; asymptotic P-value=0.004; P corr =0.032). In conclusion, this study demonstrated that certain VDR and RXRA SNPs may be risk factors for OC in non-carriers of BRCA1/BRCA2 mutations in the Polish population.

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“…Expression analysis of cancer cell lines indicated substantially reduced expression of miR-498 (Kasiappan et al, 2012). Therefore it will be interesting to note if miR-498 reconstitution will be helpful in suppressing ovarian cancer.…”

Section: Tumor Suppressormentioning

confidence: 99%

Ovarian Cancer: Interplay of Vitamin D Signaling and miRNA Action

Attar

Gasparri²,

Donato³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Increasing attention is being devoted to the mechanisms by which cells receive signals and then translate these into decisions for growth, death, or migration. Recent findings have presented significant breakthroughs in developing a deeper understanding of the activation or repression of target genes and proteins in response to various stimuli and of how they are assembled during signal transduction in cancer cells. Detailed mechanistic insights have unveiled new maps of linear and integrated signal transduction cascades, but the multifaceted nature of the pathways remains unclear. Although new layers of information are being added regarding mechanisms underlying ovarian cancer and how polymorphisms in VDR gene influence its development, the findings of this research must be sequentially collected and re-interpreted. We divide this multi-component review into different segments: how vitamin D modulates molecular network in ovarian cancer cells, how ovarian cancer is controlled by tumor suppressors and oncogenic miRNAs and finally how vitamin D signaling regulates miRNA expression. Intra/inter-population variability is insufficiently studied and a better understanding of genetics of population will be helpful in getting a step closer to personalized medicine.

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1,25-Dihydroxyvitamin D3 Suppresses Telomerase Expression and Human Cancer Growth through MicroRNA-498

Cited by 113 publications

References 57 publications

Vitamin D in cancer chemoprevention

Vitamin D in cancer chemoprevention

Polymorphic variants in the vitamin D pathway genes and the risk of ovarian cancer among non-carriers of BRCA1/BRCA2 mutations

Ovarian Cancer: Interplay of Vitamin D Signaling and miRNA Action

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