1,3,4-Oxadiazines and 1,3,4-Thiadiazines

Pfeiffer, W.‐D.

doi:10.1016/b978-008044992-0.00808-7

Cited by 9 publications

(1 citation statement)

References 110 publications

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“…В связи с этим представляет интерес исследо-вать противогликозилирующую актив-ность веществ, способных трансфор-мироваться в тиольные производные. К таким соединениям относятся 1,3,4-ти-адиазины -шестичленные гетероци-клические соединения, содержащие два атома азота и один атом серы [1].…”

Section: Introductionunclassified

Sulfur-containing heterocyclic compounds with potential antidiabetic activity

et al. 2014

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The essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit the reaction of non-enzymatic glycosylation of proteins in vitro was held, and 11 the most active compounds of them were selected, also the relationship «structure – activity» was investigated. An essential part of the pathogenesis of diabetes mellitus and its complications is non-enzymatic glycosylation of proteins. However, modern endocrinology lacks clinically effective medicines for its correction.

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Section: Introductionunclassified

Sulfur-containing heterocyclic compounds with potential antidiabetic activity

et al. 2014

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Catalytic Asymmetric Aza‐Diels‐Alder Reaction: Pivotal Milestones and Recent Applications to Synthesis of Nitrogen‐Containing Heterocycles

2021

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In this review, the pivotal achievements and recent advances in catalytic asymmetric aza‐DAR reported up to 2020 are retrospectively considered and their potency for enantioselective synthesis of useful chiral piperidine, quinoline, pyridazine, oxazine and oxadiazine derivatives and fused compounds of higher molecular complexity bearing these pharmacology‐relevant heterocyclic scaffolds is demonstrated. The reported data are systematized according both to key electron transfer modes (normal or invers electron demand reactions) and to main types of attainable heterocyclic products. Of significant attention are an analysis of activation strategies (complexation, enamine or enolate formation, H‐bonding, etc.) applicable to reactions with particular types of dienes and dienophiles and identification of plausible reaction pathways (either concerted or stepwise) over stereoselective cyclization processes. The review contains 310 references and 122 synthetic schemes.

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[4+2] Cycloaddition of Ketenes with N‐Benzoyldiazenes Catalyzed by N‐Heterocyclic Carbenes

Huang

Shao

et al. 2008

Angewandte Chemie

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Enantioselektivitätsschalter: Die Enantioselektivität der hier vorgestellten, durch N‐heterocyclische Carbene (NHCs) katalysierten [4+2]‐Cycloaddition zwischen Alkylarylketenen und N‐Aryl‐N′‐benzoyldiazenen oder N,N′‐Dibenzoyldiazenen zu 1,3,4‐Oxadiazin‐6‐onen 1 konnte in den meisten Fällen durch Wechsel der Substituenten des NHC‐Katalysators umgekehrt werden. TBS=tert‐Butyldimethylsilyl, Mes=2,4,6‐Trimethylphenyl.

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1,3,4-Oxadiazines and 1,3,4-Thiadiazines

Cited by 9 publications

References 110 publications

Sulfur-containing heterocyclic compounds with potential antidiabetic activity

Sulfur-containing heterocyclic compounds with potential antidiabetic activity

Catalytic Asymmetric Aza‐Diels‐Alder Reaction: Pivotal Milestones and Recent Applications to Synthesis of Nitrogen‐Containing Heterocycles

[4+2] Cycloaddition of Ketenes with N‐Benzoyldiazenes Catalyzed by N‐Heterocyclic Carbenes

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