1,3,5,6-Tetrahydroxyxanthone, a natural xanthone, induces diuresis and saluresis in normotensive and hypertensive rats

Mariano, Luísa Nathália Bolda; Boeing, Thaise; Silva, Rita de Cássia Melo Vilhena de Andrade Fonseca da; Cechinel‐Filho, Valdir; Niero, Rivaldo; Silva, Luísa Mota da; Souza, Priscila de; Andrade, Sérgio Faloni de

doi:10.1016/j.cbi.2019.108778

Cited by 20 publications

(22 citation statements)

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“…The authors suggest that the differences found are related to the chemical constituents (composition and quantity) of the fractions. This study also demonstrated that the isolated compounds 1,3,5,6tetrahydroxyxanthone and (−)-epicatechin appear to contribute significantly to the diuretic effect found [41].…”

Section: Brazilian Medicinal Plants With Diuretic Potentialsupporting

confidence: 59%

“…Other Brazilian medicinal plants of interest with reported diuretic activity Some Brazilian plants, despite being used in traditional medicine for purposes other than diuretics, have been submitted to biological tests by our research group, mainly due to their wide geographical distribution and the variety of chemical compounds in their composition: Garcinia achachairu Rusby [41], Marlierea eugeniopsoides (D.Legrand & Kausel) D.Legrand [42], and Mimosa bimucronata (DC.) Kuntze [43].…”

Section: Brazilian Medicinal Plants With Diuretic Potentialmentioning

confidence: 99%

“…Concerning its safety, when 1 was given to humans in different doses, it proved to be safe with no observed adverse effects [51]. We also considered a xanthone isolated from G. achachairu branches in our lab [41], identified as 1,3,5,6-tetrahydroxyxanthone [2]. Xanthones are a class of polyphenolic compounds that are widely found in plants and present beneficial cardiovascular effects.…”

Section: Isolated Compounds From Brazilian Medicinal Plants With Diurmentioning

confidence: 99%

“…Its combination with furosemide or hydrochlorothiazide resulted in an increase in urinary volume. Furthermore, 2-induced diuresis was enhanced after pretreatment with L-NAME, and its ability to enhance urinary elimination was not prevented in the presence of either indomethacin or atropine [41]. Kaempferitrin [3] (kaempferol 3,7-dirhamnoside), a kaempferol-derived flavone found in some plant species, is the main chemical compound of B. forficata leaves and is related to the pharmacological activity of this species [55,56].…”

Section: Isolated Compounds From Brazilian Medicinal Plants With Diurmentioning

confidence: 99%

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Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

et al. 2020

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Medicinal plants are used in traditional medicine to treat a wide range of ailments. The knowledge of them is handed down from generation to generation and is described in several pharmacopoeia and in the general literature. The immense biodiversity of the Brazilian flora, covering about 25% of all plant species worldwide, makes Brazil a huge potential source of medicinal plants. Indeed, many of these plant species are already used in the Brazilian ethnopharmacology for their probable effect to induce diuresis, to reduce fluid retention, and to treat cardiovascular and renal disorders. This review article describes and discusses the main native Brazilian medicinal plants (including some of their isolated compounds) used as diuretics. It also gives a comprehensive analysis of the most relevant scientific studies presented to date, as well as addressing a special topic with future prospects for plant species that have not yet been scientifically studied. In brief, several plants can be indicated for more detailed study, with a view to obtain scientific subsidies for a new and effective diuretic medicine in the future. These include Bauhinia forficata, Leandra dasytricha, and Tropaeolum majus. Other species have reputed medicinal properties but lack experimental assays to demonstrate their pharmacological effects (e.g., Mikania hirsutissima, Phyllanthus niruri, and Tagetes minuta). Several active principles are indicated as responsible for the diuretic effects of the plants studied, with emphasis on phenolic compounds as flavonoids, phenolic acids, and xanthones. These results should encourage more detailed preclinical, clinical, and phytochemical investigations on Brazilian plants in the future.

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Section: Brazilian Medicinal Plants With Diuretic Potentialsupporting

confidence: 59%

Section: Brazilian Medicinal Plants With Diuretic Potentialmentioning

confidence: 99%

Section: Isolated Compounds From Brazilian Medicinal Plants With Diurmentioning

confidence: 99%

Section: Isolated Compounds From Brazilian Medicinal Plants With Diurmentioning

confidence: 99%

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Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

et al. 2020

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“…Natural product xanthones (dibenzo-γ-pyrones) constitutes a significant class of oxygenated heterocycles and occurs as secondary metabolites in microorganisms and plants. 7 This kind of metabolites showed numerous pharmacological activities such as anti-cancer, 8 antioxidant, 9 diuresis and saluresis, 10 hepatoprotective, 11 anti-gout, 12 anti-inflammatory, 13 anti-diabetes, 14 and gastroprotective. 15 Recently, these xanthones easily incorporated into micro-molecules attributing to intriguing biological activities had drew attention from phytochemical, 16 organic synthesis, 17,18 and pharmacological endeavors.…”

Section: Introductionmentioning

confidence: 99%

<p>Anti-Tumor Xanthones from <em>Garcinia nujiangensis</em> Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells</p>

Tang¹,

Lu²,

Xia³

2020

DDDT

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Background: Ovarian cancer (OC) is a serious public health concern in the world. It is important to develop novel drugs to inhibit OC. Purpose: This study investigated the isolation, elucidation, efficiency, molecular docking, and pharmaceutical mechanisms of xanthones isolated from Garcinia nujiangensis. Methods: Xanthones were isolated, and purified by different chromatography, including silica gel, reversed-phase silica gel (ODS-C 18), and semipreparative HPLC, then identified by analysis of their spectral data. Three xanthones were estimated for their efficiency on the human OC cells HEY and ES-2. 2 was found to be the most potent cytotoxic xanthones of those tested. Further, its mechanisms of action were explored by molecular docking, cell apoptosis, and Western blotting analysis. Results: Bioassay-guided fractionation of the fruits of Garcinia nujiangensis led to the separation of a new xanthone named nujiangexanthone G (1) and two known xanthones. Among these, isojacareubin (2) exhibited the most potent cytotoxic compound against the HEY and ES-2 cell lines. The analysis of Western blot suggested that 2 inhibited OC via regulating the PARP, PI3K/ AKT/mTOR, and ERK/MAPK signal pathways in the HEY cell lines. Conclusion: In conclusion, isojacareubin (2) might be a potential drug for the treatment of OC.

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Diuretic and Antiurolithic Effect of Garcinia humilis (Vahl) C.D. Adams Leaves, a Medicinal Plant Native to South American Countries

Mariano

Pontioli

Silva

et al. 2022

Chemistry & Biodiversity

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This study evaluated the diuretic and antiurolithic effect of methanolic extract (MEGHL), dichloromethane (DCM), and ethyl acetate (EtA) fractions obtained from the leaves of Garcinia humilis, a medicinal plant known as achachairu and native to South American countries such as Bolivia, Peru, and Brazil. For the analysis of diuretic effect, the female rats received the treatment with MEGHL (3, 10, and 30 mg/kg), DCM (1, 3 and 10 mg/kg), EtA (1, 3, and 10 mg/kg), hydrochlorothiazide (HCTZ; 10 mg/kg), or vehicle (VEH) after an overload of saline solution. At the end 8 h of the experiment, the urinary parameters were measured. Additionally, the antiurolithic effect was analyzed, in which sodium oxalate was added in synthetic urine in the presence or absence of MEGHL, DCM, and EtA in different concentrations (0.1, 0.3, and 1 mg/mL). MEGHL, DCM, and EtA were able to promote 8-h diuresis in rats. MEGHL treatment at dose 30 mg/kg was accompanied by increased urinary Na + , K + and Cl À excretion. Moreover, the DCM and EtA fractions treatment increased K + and Cl À excretion in the urine, although it does not cause any change in Na + elimination. All the preparations were able to exert an antiurolithic effect in vitro, decreasing the number of calcium oxalate crystals of the monohydrate and dihydrate types. Taking together, the results presented herein showed that the preparations of G. humilis leaves are promising strategies to induce diuresis and antiurolithic effects.

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1,3,5,6-Tetrahydroxyxanthone, a natural xanthone, induces diuresis and saluresis in normotensive and hypertensive rats

Cited by 20 publications

References 61 publications

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

<p>Anti-Tumor Xanthones from <em>Garcinia nujiangensis</em> Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells</p>

Diuretic and Antiurolithic Effect of Garcinia humilis (Vahl) C.D. Adams Leaves, a Medicinal Plant Native to South American Countries

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