1,3-Dibromo-5,5-dimethylhydantoin catalyzed one-pot synthesis of 2-arylbenzothiazoles

Abstract

A one-pot synthesis of 2-arylbenzothiazoles from the reaction of 2-aminothiophenol and aromatic aldehydes catalyzed by 1,3-dibromo-5,5-dimethylhydantoin is reported.

Use of Bromine and Bromo-Organic Compounds in Organic Synthesis

“…This method was also carried out under solvent-free conditions. 2-Arylbenzothiazoles were efficiently synthesized in one pot from the reaction of 2-aminothiophenol and aromatic aldehydes using DBH as the catalyst .…”

“…2-Arylbenzothiazoles were efficiently synthesized in one pot from the reaction of 2-aminothiophenol and aromatic aldehydes using DBH as the catalyst. 2254 A similar protocol was developed under BDMS catalysis. 2255 Shirini developed a methodology for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthenes using DBH as the catalyst in the presence of kaolin under solvent-free conditions (Scheme 844).…”

Valorization of the Phosphate Fertilizers Catalytic Activity in 1-(Benzothiazolylamino) Methyl-2-Naphthol Derivatives Synthesis

“…In particular, 2-aminobenzothiazole is mentioned which is widely used in the fields of medicinal chemistry and biology [3]. They present anti-inflammatory [4], anti-fungal [5] antibacterial [6], anticonvulsant [7], anticancer [8], antitumor [9] activities. They also found their application as indicators of Alzheimer's disease [10], and they are served as reactive and hair dyes [11][12].…”