1,3-Dipolar Cycloaddition of Dipolar Reagents to Bifunctional Olefins in the Presence of Chloramine-T (CAT)

Abstract

2-Pyrazolines and 2-isoxazolines are prepared by the reaction of araldehyde hydrazones and araldoximes with bifunctional olefins in the presence of chloramine-T, which also functions as a reagent for aromatization of the former.

Synthesis of 5-arylazothiazoles, pyridines and thieno[2,3-b]pyridines derivatives containing 1,2,3-triazole moiety

“…Some of these compounds have also anti-inflammatory, antidiabetic, anaesthetic and analgesic properties [7][8][9]. In addition, pyrazolines have played a crucial part in the development of theory in heterocyclic chemistry and also been used extensively in organic synthesis [10][11][12][13][14]. On the other hand, thienopyrimidine derivatives are characterized by a very broad spectrum of biological activities such as antiallergic [15], antiatherosclerotic [16], antibacterial [17][18][19], anticancer [20], antiviral [21,22], antihypertensive [23,24], antidepressant [25], antihistaminic [26], antimicrobial [27][28][29][30][31] and neurotropic [32] activities.…”

Extraction and determination of 2-pyrazoline derivatives using liquid phase microextraction based on solidification of floating organic drop

“…Moreover, pyrazolines and pyrazoles play a crucial role in the development of theory in heterocyclic chemistry and also are extensively used as useful synthons in organic synthesis [6]. 2-Pyrazolines and the corresponding pyrazoles have been shown to possess antitumor, anesthetic, analgesic, tranquilizer, muscle relaxant, antidepressant, neuroleptic, hypnotic, anticonvulsant, anti-inflammatory, antipyretic, antidiabetic, antiarrhythmic, antibacterial, antifungal, antiparasitic, antituberculosis, and insecticidal activities [7][8][9].…”

Recent progress in the application of N-halo reagents in the synthesis of heterocyclic compounds

“…The generated 2-pyrazolines were also oxidized to the corresponding pyrazoles in the course of the reaction (Scheme 43). 81 The thiadiazolidinone (TDZD) ring system (Fig. 1) possesses several interesting pharmacological properties.…”