1,4-Dihydropyrimido[1,2-a]benzimidazoles and their biological activity

Synthesis of pyrimido[1,2-a]benzimidazoles from ethyl 2-ethoxymethylidene-3-oxo-3-(polyfluoroalkyl)propionates

“…Up to now, numerous data have been reported on regioselective cyclizations of benzimidazol-2-amine with diethyl malonate and ethyl cyanoacetate [7], 1,3-diketones [7,8], 3-oxo esters and their derivatives [7,9], α,β-unsaturated ketones (chalcones) [4,[10][11][12], and cinnamic acid esters [13]. Initial compounds may also be 1,3-bielectrophiles having an additional electrophilic center.…”

“…These heterocycles are structurally related to natural purine bases, which determines versatile biological activity of their derivatives [1]. Compounds exhibiting antibacterial [2], anticarcinogenic [3], neurotropic [4], tranquilizing [5], and antiarrhythmic [6] effect were found among pyrimido[1,2-a]benzimidazole derivatives.…”