1,4-Dioxane. I. Results of a 2-year ingestion study in rats

Kociba, R.J.; McCollister, Susan B.; Park, C.; Torkelson, T. R.; Gehring, P.J.

doi:10.1016/0041-008x(74)90099-4

Cited by 108 publications

(36 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Purified water was prepared using a Milli-Q water purification PSS20 system (Millipore Corp., Bedford, MA, U.S.A.). Preparation of Standard Solutions ---Standard solutions of 1,4-dioxane and 1,4-dioxane-d 8 were prepared in dichloromethane from stock solutions of 1 mg/ml 1,4-dioxane and 10 mg/ml 1,4-dioxaned 8 as described previously.…”

Section: Methodsmentioning

confidence: 99%

“…6) With regard to a cancer endpoints, a TDI of 16 µg of 1,4-dioxane/kg body weight/day has been calculated by applying an uncertainty factor of 1000 to the level of 16 µg/kg body weight/day at which no adverse effects were observed in a longterm study of drinking water in rats. 15,16) This uncertainty factor incorporates 100 for inter-and intraspecies variation and 10 for nongenotoxic carcinogenicity. An intake of 4.5 µg of 1,4-dioxane corresponded to 0.56% of the TDI (4.5 µg/{16 µg/kg body weight/day × 50 kg}).…”

Section: Content Of 14-dioxane In the Mixed Meal Samplesmentioning

confidence: 99%

“…× 1.4-µm film thickness) (SigmaAldrich Co., Ltd.), as reported previously. 1) In the selected ion monitoring (SIM) mode, the monitoring ions were 58 and 88 for 1,4-dioxane and 64 and 96 for 1,4-dioxane-d 8 . A calibration curve was prepared from the ratio of the peak height of 1,4-dioxane and 1,4-dioxane-d 8 .…”

Section: )mentioning

confidence: 99%

“…There is evidence that long-term oral administration of 1,4-dioxane in rodents causes hepatic and nasal cavity tumors in rodents, [8][9][10][11][12] and accordingly the IARC has classified 1,4-dioxane as a group 2B carcinogen. 6) With regard to a cancer endpoints, a TDI of 16 µg of 1,4-dioxane/kg body weight/day has been calculated by applying an uncertainty factor of 1000 to the level of 16 µg/kg body weight/day at which no adverse effects were observed in a longterm study of drinking water in rats.…”

Section: Content Of 14-dioxane In the Mixed Meal Samplesmentioning

confidence: 99%

“…[5][6][7][8] Studies in mice using a two-stage carcinogenic test have demonstrated 1,4-dioxane also has promoter activity. 9) In 2003, 1,4-dioxane was added to the revised water quality standards in Japan.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Study of 1,4-Dioxane Intake in the Total Diet

Nishimura

Iizuka

Kibune

et al. 2005

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

1,4-Dioxane is a newly added compound to the water quality standards in Japan that were revised in 2003. In order to estimate the contribution of 1,4-dioxane in drinking water to the total exposure in humans, it is necessary to take into account the quantity of the compound in food. In an earlier study, we measured the intake of 1,4-dioxane in food based on the average consumption of food in the Kanto area.1) The total daily intake of 1,4-dioxane was calculated to be 0.440 g. In the present study, we investigated the intake of 1,4-dioxane from food by sampling meals from 3 days from 3 homes in 9 prefectures, respectively. 1,4-Dioxane was extracted from 20 g of homogenates of mixed meals using the steam distillation, concentrated by a solid phase cartridge and then measured using gas-chromatography/mass spectrometry. The detection limit of the analysis was 2 g/kg. No 1,4-dioxane was detected in 26 samples, while 3 g/kg was detected in one sample. In this sample case, the daily intake of the 1,4-dioxane was calculated as 4.5 g that represented 0.56% of the total daily intake (TDI) (4.5 g/{16 g/ kg body weight/day ؋ 50 kg}).

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Content Of 14-dioxane In the Mixed Meal Samplesmentioning

confidence: 99%

Section: )mentioning

confidence: 99%

Section: Content Of 14-dioxane In the Mixed Meal Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Study of 1,4-Dioxane Intake in the Total Diet

Nishimura

Iizuka

Kibune

et al. 2005

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

show abstract

1,4-Dioxane is not mutagenic in five in vitro assays and mouse peripheral blood micronucleus assay, but is in mouse liver micronucleus assay

Morita¹,

Hayashi

1998

Environ. Mol. Mutagen.

View full text Add to dashboard Cite

Ethers of Ethylene Glycol and Derivatives

Kelsey

2023

Patty's Toxicology

View full text Add to dashboard Cite

E series Glycol ethers are alkyl ethers of ethylene glycol along with their acetate esters. They are commonly used in paints and cleaners and typically have a higher boiling point in conjunction with the favorable solvent properties of lower‐molecular weight ethers, esters, and alcohols. They are colorless liquids that have mild earthy or fruity odors. The ethers are miscible with water and/or with numerous organic solvents making them useful as solvents in oil‐water compositions. Their relatively slow rate of evaporation also makes them useful as solvents and coalescing agents in paints and inks. The surface tension and solvent properties of the ethers make them useful in cleaners. Other uses of the ethers include process solvents and deicers. The ethers of the higher glycols are used as hydraulic fluids. Occupational exposure to glycol ethers occurs dermally and by inhalation. Most glycol ethers have low acute, single‐dose toxicity to humans. The most notable and well‐known effect relevant to humans is toxicity to male fertility and developmental toxicity produced by those glycol ethers that can metabolize to produce significant amounts of methoxyacetic acid such as methoxy ethanol and the methyl glymes.

show abstract

1,4-Dioxane. I. Results of a 2-year ingestion study in rats

Cited by 108 publications

References 5 publications

Study of 1,4-Dioxane Intake in the Total Diet

Study of 1,4-Dioxane Intake in the Total Diet

1,4-Dioxane is not mutagenic in five in vitro assays and mouse peripheral blood micronucleus assay, but is in mouse liver micronucleus assay

Ethers of Ethylene Glycol and Derivatives

Contact Info

Product

Resources

About