1.5-μm resolution optical low-coherence reflectometry in biological tissues

Clivaz, X.; Marquis‐Weible, F.; Salathé, René-Paul

doi:10.1117/12.167408

Cited by 16 publications

(11 citation statements)

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“…23,39 These systems were carefully designed to compensate for the dispersion of the optical elements within the measurement and the reference arm of the interferometer. The additional dispersive effects of a few hundred micrometers of tissue have only a negligible effect on the signal width and hence the resolution.…”

Section: Discussionmentioning

confidence: 99%

Signal and Resolution Enhancements in Dual Beam Optical Coherence Tomography of the Human Eye

et al. 1998

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In the past 10 years, a dual beam version of partial coherence interferometry has been developed for measuring intraocular distances in vivo with a precision on the order of 0.3 to 3 μm. Two improvements of this technology are described. A special diffractive optical element allows matching of the wavefronts of the divergent beam reflected at the cornea and the parallel beam reflected at the retina and collimated by the optic system of the eye. In this way, the power of the light oscillations of the interfering beams incident on the photodetector is increased and the signal-to-noise ratio of in vivo measurements to the human retina is improved by 20 to 25 dB. By using a synthesized light source consisting of two spectrally displaced superluminescent diodes with an effective bandwidth of 50 nm, and by compensating for the dispersive effects of the ocular media, it was possible to record the first optical coherence tomogram of the retina of a human eye in vivo with an axial resolution of ∼6 to 7 μm. This is a twofold improvement over the current technology. © 1998 Society of Photo-Optical Instrumentation Engineers.

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Section: Discussionmentioning

confidence: 99%

Signal and Resolution Enhancements in Dual Beam Optical Coherence Tomography of the Human Eye

et al. 1998

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“…This corresponds to the case of Fig. 2a and to the images recorded with the Humphrey OCT. Systems with higher resolution using broadband Ti:Al 2 O 3 sources have so far been used only for ranging and imaging within tissues with a total thickness of a few hundred micrometers [3,6]. In this case, the dispersive effect of the thin tissue has a negligible effect on the signal width and hence on the resolution.…”

Section: Discussionmentioning

confidence: 99%

Resolution-improved dual-beam and standard optical coherence tomography: a comparison

Baumgärtner¹,

Hitzenberger²,

Erdem

et al. 2000

Graefe's Archive for Clinical and Experimental Ophthalmology

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“…With the use of broadband Ti:Al 2 O 3 sources, resolution figures on the order of 2-4 m (in air) were demonstrated. 11,12 These sources were applied to PCI ranging and OCT imaging of biologic samples of a total thickness of a few hundred micrometers.…”

Section: Introductionmentioning

confidence: 99%

Dispersion Effects in Partial Coherence Interferometry: Implications for Intraocular Ranging

et al. 1999

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In nondispersive media, the minimum distance that can be resolved by partial coherence interferometry (PCI) and optical coherence tomography (OCT) is inversely proportional to the source spectral bandwidth. Dispersion tends to increase the signal width and to degrade the resolution. We analyze the situation for PCI ranging and OCT imaging of ocular structures. It can be shown that for each ocular segment an optimum source bandwidth yielding optimum resolution exists. If the resolution is to be improved beyond this point, the group dispersion of the ocular media has to be compensated. With the use of a dispersion compensating element, and employing a broadband superluminescent diode, we demonstrate a resolution of 5 μm in the retina of both a model eye and a human eye in vivo. This is an improvement by a factor of 2-3 as compared to currently used instruments. © 1999 Society of Photo-Optical Instrumentation Engineers.

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1.5-μm resolution optical low-coherence reflectometry in biological tissues

Cited by 16 publications

References 0 publications

Signal and Resolution Enhancements in Dual Beam Optical Coherence Tomography of the Human Eye

Signal and Resolution Enhancements in Dual Beam Optical Coherence Tomography of the Human Eye

Resolution-improved dual-beam and standard optical coherence tomography: a comparison

Dispersion Effects in Partial Coherence Interferometry: Implications for Intraocular Ranging

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