Resolution-improved dual-beam and standard optical coherence tomography: a comparison

Abstract

Dual-beam OCT is able to provide structural information on the ocular fundus that is not obtained with standard OCT. The long recording times of our instrument limit the transverse resolution to 100-150 microm at present.

Histopathological correlation of corneal diseases with optical coherence tomography

“…Despite the high resolution, we observed that this clinical OCT system was limited to relatively large morphological changes, compared with LM. Refinements of the current imaging modalities with shorter coherence lengths or broader spectral bandwidths, such as dual-beam OCT [1] or ultra-high-resolution OCT, reaching a resolution of 2 µm in the cornea [5], combined with advanced scanning methods [25] could enable us to visualize the microstructural details and cellular layers more precisely, and eventually allow more detailed diagnostic imaging of tissue morphology without the need for excision of specimens [7]. Thus, with certain limitations, the current slitlamp-adapted OCT system can provide a noncontact optical biopsy of the corneal structures, and could be helpful to investigate, diagnose and monitor corneal diseases.…”

Modeling of low coherence interferometry using broadband multi-Gaussian light sources

“…This resulted in a reduction in the coherence length from 12 μm to 8 μm [28]. Wang [29] showed another multi-SLD example, which was a combination of four SLDs with central wavelength/bandwidth combinations of 1265 nm/30 nm, 1320 nm/70 nm, 1355 nm/53 nm, and 1380 nm/47 nm.…”

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

“…The classic interferometric setup of partial coherence interferometry (PCI) and OCT has the drawback of being sensitive to longitudinal object positions [440]. Efforts to overcome such limitations in ocular media have been reported, in which the cornea was used as a reference surface in a common path dual-beam interferometric set-up [441].…”