1-Aminocyclopropane-1-carboxylic acid oxidase reaction mechanism and putative post-translational activities of the ACCO protein

Dilley, David R.; Wang, Zhenyong; Kadirjan-Kalbach, Deena K.; Ververidis, Filippos; Beaudry, Randolph M.; Padmanabhan, Kallaithe

doi:10.1093/aobpla/plt031

Cited by 38 publications

(40 citation statements)

References 62 publications

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“…However, differential accumulation of specific ACO transcripts is observed during various physiological processes and environmental conditions (De Paepe and Van Der Straeten, 2005 ; Argueso et al, 2007 ; Lin et al, 2009 ; Ruduś et al, 2012 ). Several ACO genes were shown to be auto-regulated by ethylene (De Paepe et al, 2004 ) and recently, evidence is suggesting post-transcriptional/translational regulation mechanisms for ACO as well (Dilley et al, 2013 ; Van de Poel et al, 2014 ; Van de Poel and Van Der Straeten, 2014 ).…”

Section: Metal Stress Affects Ethylene Biosynthesis and Signaling At mentioning

confidence: 99%

Ethylene and Metal Stress: Small Molecule, Big Impact

et al. 2016

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The phytohormone ethylene is known to mediate a diverse array of signaling processes during abiotic stress in plants. Whereas many reports have demonstrated enhanced ethylene production in metal-exposed plants, the underlying molecular mechanisms are only recently investigated. Increasing evidence supports a role for ethylene in the regulation of plant metal stress responses. Moreover, crosstalk appears to exist between ethylene and the cellular redox balance, nutrients and other phytohormones. This review highlights our current understanding of the key role ethylene plays during responses to metal exposure. Moreover, particular attention is paid to the integration of ethylene within the broad network of plant responses to metal stress.

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Section: Metal Stress Affects Ethylene Biosynthesis and Signaling At mentioning

confidence: 99%

Ethylene and Metal Stress: Small Molecule, Big Impact

et al. 2016

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“…Although the hydrogen cyanide is ultimately metabolised, primarily by β-cyanoalanine synthase to produce the amino acid β-cyanoalanine (10), coordination to the iron center of ACC oxidase would seem likely beforehand. A recent publication by Dilley et al (11) revealed that ACC oxidase is activated at cyanide concentrations between 0.1 to 1 mM whereas above 1 mM the cyanide becomes inhibitory. These authors propose that cyanide is bound as a ligand to Fe(II) in ACC oxidase, which then assists ACC binding.…”

Section: Main Textmentioning

confidence: 99%

A Simple Complex on the Verge of Breakdown: Isolation of the Elusive Cyanoformate Ion

Murphy

Robertson

Harroun

et al. 2014

Science

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Why does cyanide not react destructively with the proximal iron center at the active site of 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase, an enzyme central to the biosynthesis of ethylene in plants? It has long been postulated that the cyanoformate anion, [NCCO2]–, forms and then decomposes to carbon dioxide and cyanide during this process. We have now isolated and crystallographically characterized this elusive anion as its tetraphenylphosphonium salt. Theoretical calculations show that cyanoformate has a very weak C–C bond and that it is thermodynamically stable only in low dielectric media. Solution stability studies have substantiated the latter result. We propose that cyanoformate shuttles the potentially toxic cyanide away from the low dielectric active site of ACC oxidase before breaking down in the higher dielectric medium of the cell.

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“…The ACO proteins that catalyze the oxidation of ACC to ethylene are encoded by a small family of genes (usually 3–4) that belong to a large superfamily of ferrous-dependent non-heme oxygenases ( Ruduś et al , 2013 ). Phylogenetic analysis clusters PsACO1, PsACO2, and PsACO3 with functional ACC oxidases, and all three proteins contain amino acids known to be important for ACO activity ( Dilley et al , 2013 ; Booker and DeLong, 2015 ; see Supplementary information; Supplementary Protocol S4 ; Supplementary Figs S4 , S5 ).…”

Section: Resultsmentioning

confidence: 99%