1-Ethyl-4′-(1H-indol-3-ylcarbonyl)-1′-methyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carbonitrile dimethyl sulfoxide monosolvate

Abstract

In the title compound, C31H25N5O3·C2H6OS, the three indole/indoline units are all essentially planar with maximum deviations of 0.0172 (3), 0.053 (2) and 0.07 (2) Å. The pyrrolidine ring adopts an envelope conformation with the C atoms bearing the 1-ethyl-2-oxo­indole substituent (in which the five-membered ring adopts a twisted conformation) as the flap. The dimethyl sulfoxide solvent mol­ecule is disordered over two positions, with an occupancy factor ratio of 0.871 (4):0.129 (4). The solvent components are linked to the heterocyclic mol­ecule via C—H⋯O and C—H⋯S hydrogen bonds. In the crystal, the solvent components are linked to the heterocyclic molecule via C—H⋯O and C—H⋯S inter­actions, forming R 2 2(10) ring motifs. The mol­ecules are further connected into a chain along the a-axis direction via N—H⋯O hydrogen bonds.

3′-[(1H-Indol-3-yl)carbonyl]-1′-methyl-2-oxo-4′-(thiophen-2-yl)spiro[indoline-3,2′-pyrrolidine]-3′-carbonitrile

“…Both the indole and oxindole moieties are individually quite planar and the dihedral angle between them is 34.22 (11)°. The title compound exhibits structural similarities with the previously reported related structure (Inglebert et al, 2013).…”

“…For graph-set notation, see: Bernstein et al (1995). For a related structure, see: Inglebert et al (2013).…”

4′-(1H-Imidazol-2-yl)-3′-[(1H-indol-3-yl)carbonyl]-1′-methyl-2-oxospiro[indoline-3,2′-pyrrolidine]-3′-carbonitrile 0.15-hydrate

“…The H atoms of the partial occupancy water molecules are neither located nor included in the refinement. The title structure exhibits structural similarities with the previously reported structure (Inglebert et al, 2013).…”

“…For graph-set notation, see: Bernstein et al (1995). For a related structure, see: Inglebert et al (2013). (8) 138(2) N6-H6AÁ Á ÁO1 0.90 (1) 2.57 (2) 3.064 2116 2Symmetry code: (i) x þ 1 2 ; Ày þ 1 2 ; z À 1 2 .…”