1 Hz repetitive transcranial magnetic stimulation of the unaffected hemisphere ameliorates contralesional visuospatial neglect in humans

Brighina, Filippo; Bisiach, Edoardo; Oliveri, Massimiliano; Piazza, Aurelio; Bua, Vincenzo; Daniele, Ornella; Fierro, Brigida

doi:10.1016/s0304-3940(02)01283-1

Cited by 204 publications

(136 citation statements)

References 9 publications

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“…The suppressive effect of 1 Hz rTMS on cortical excitability has been used to induce a temporary cortical dysfunction in healthy subjects (Kosslyn et al, 1999;Hilgetag et al, 2001;Muellbacher et al, 2002;Knecht et al, 2003) or, presumably by normalizing increased levels of excitability, to induce beneficial effects in patients with neuropsychiatric disorders (Klein et al, 1999;Siebner et al, 1999b;Tergau et al, 1999;Brighina et al, 2003;Hoffman et al, 2003). Here, we found that preconditioning with cathodal TDCS can flip the "normal" suppressive effect of 1 Hz rTMS and cause an apparently paradoxical facilitation.…”

Section: Discussionmentioning

confidence: 71%

Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex

Siebner¹,

Lang²,

Rizzo³

et al. 2004

J. Neurosci.

649

408

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Recent experimental work in animals has emphasized the importance of homeostatic plasticity as a means of stabilizing the properties of neuronal circuits. Here, we report a phenomenon that indicates a homeostatic pattern of cortical plasticity in healthy human subjects. The experiments combined two techniques that can produce long-term effects on the excitability of corticospinal output neurons: transcranial direct current stimulation (TDCS) and repetitive transcranial magnetic stimulation (rTMS) of the left primary motor cortex. "Facilitatory preconditioning" with anodal TDCS caused a subsequent period of 1 Hz rTMS to reduce corticospinal excitability to below baseline levels for Ͼ20 min. Conversely, "inhibitory preconditioning" with cathodal TDCS resulted in 1 Hz rTMS increasing corticospinal excitability for at least 20 min. No changes in excitability occurred when 1 Hz rTMS was preceded by sham TDCS. Thus, changing the initial state of the motor cortex by a period of DC polarization reversed the conditioning effects of 1 Hz rTMS. These preconditioning effects of TDCS suggest the existence of a homeostatic mechanism in the human motor cortex that stabilizes corticospinal excitability within a physiologically useful range.

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Section: Discussionmentioning

confidence: 71%

Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex

Siebner¹,

Lang²,

Rizzo³

et al. 2004

J. Neurosci.

649

408

View full text Add to dashboard Cite

show abstract

“…Several studies have used this approach, and it has been shown to be effective in both motor and non-motor deficits. For example, inhibitory rTMS to the non-lesioned parietal cortex can induce long-lasting improvements in symptoms of spatial neglect (Brighina et al 2003;Shindo et al 2006). In the motor region, Grefkes and colleagues showed that inhibitory rTMS applied over contralesional M1 of patients with subacute stroke significantly improved motor performance of the affected hand (Grefkes et al, 2010).…”

Section: Strokementioning

confidence: 99%

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Sale¹,

Mattingley²,

Zalesky³

et al. 2015

Neuroscience & Biobehavioral Reviews

127

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“…Recently, it has been reported that low-frequency rTMS is able to improve hemispatial neglect and nonfluent aphasia by the transient functional disruption of the corresponding area in the unaffected hemisphere, a phenomenon provisionally called paradoxical functional facilitation (Oliveri et al, 1999;Brighina et al, 2003;Martin et al, 2004). Moreover, other authors found similar paradoxical improvements in performances of hand movements or memory encoding after low-frequency rTMS over motor cortex or ventrolateral prefrontal cortex (Kobayashi et al, 2004;Kahn et al, 2005).…”

Section: Functional Role Of the Right Pitcmentioning

confidence: 91%

Transient Functional Suppression and Facilitation of Japanese Ideogram Writing Induced by Repetitive Transcranial Magnetic Stimulation of Posterior Inferior Temporal Cortex

et al. 2006

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The Japanese writing system is unique in that it is composed of two different orthographies: kanji (morphograms) and kana (syllabograms). The retrieval of the visual orthographic representations of Japanese kanji is crucial to the process of writing in Japanese. We used low-frequency repetitive transcranial magnetic stimulation (rTMS) to clarify the functional relevance of the left and right posterior inferior temporal cortex (PITC) to this process in native Japanese speakers. The experimental paradigms included the mental recall of kanji, kana-to-kanji transcription, semantic judgment, oral reading, and copying of kana and kanji. The first two tasks require the visualization of the kanji image of the word. We applied 0.9 Hz rTMS (600 total pulses) over individually determined left or right PITC to suppress cortical activity and measured subsequent task performance. In the mental recall of kanji and kana-to-kanji transcription, rTMS over the left PITC prolonged reaction times (RTs), whereas rTMS over the right PITC reduced RTs. In the other tasks, which do not involve the mental visualization of kanji, rTMS over the left or right PITC had no effect on performance. These results suggest that the left PITC is crucial for the retrieval of the visual graphic representation of kanji. Furthermore, the right PITC may work to suppress the dominant left PITC in the neural network for kanji writing, which involves visual word recognition.

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1 Hz repetitive transcranial magnetic stimulation of the unaffected hemisphere ameliorates contralesional visuospatial neglect in humans

Cited by 204 publications

References 9 publications

Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex

Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Transient Functional Suppression and Facilitation of Japanese Ideogram Writing Induced by Repetitive Transcranial Magnetic Stimulation of Posterior Inferior Temporal Cortex

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