1-O-hexadecyl-2-metoxy-glycero-3-phosphatidylcholine—A methoxy ether lipid inhibiting platelet activating factor-induced platelet aggregation and neutrophil oxidative metabolism

Blanc, Katarina Le; Samuelsson, Jan; Brohult, Johan; Berg, Anders; Palmblad, Jan

doi:10.1016/0006-2952(95)00099-l

Cited by 4 publications

(1 citation statement)

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“…[38] studied if Et-16-OCH 3 and 1-0-hexadecyl- sn -glycerol (chimyl alcohol) possessed the ability to induce functional responses in platelets and chemiluminescence in neutrophils and whether they could modify the response induced by PAF. Et-16-OCH 3 (1–100 μM) induced platelet aggregation but CA did not.…”

Section: Alkylglycerols Studiesmentioning

confidence: 99%

An Update on the Therapeutic Role of Alkylglycerols

Iannitti

Palmieri

2010

Marine Drugs

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Scandinavian folk medicine used shark liver oil for the treatment of cancers and other ailments based on the rarity of tumors in sharks and their ability to resist infections. Shark liver oil is a source of alkylglycerols which have been studied as anti-cancer agents in several clinical trials. Moreover, alkylglycerols have been investigated for the treatment of radiation induced side effects and for their ability to boost the immune system. Several experimental studies have shown the ability of alkylglycerols to open the blood brain barrier to facilitate the access of therapeutic drugs to the central nervous system. This review covers the most important studies of alkylglycerols in both animals and humans.

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Section: Alkylglycerols Studiesmentioning

confidence: 99%

An Update on the Therapeutic Role of Alkylglycerols

Iannitti

Palmieri

2010

Marine Drugs

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The importance of ether-phospholipids: A view from the perspective of mouse models

Silva

Sousa

Malheiro³

et al. 2012

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Ether-phospholipids represent an important group of phospholipids characterized by an alkyl or an alkenyl bond at the sn-1 position of the glycerol backbone. Plasmalogens are the most abundant form of alkenyl-glycerophospholipids, and their synthesis requires functional peroxisomes. Defects in the biosynthesis of plasmalogens are the biochemical hallmark of the human peroxisomal disorder Rhizomelic Chondrodysplasia Punctata (RCDP), which is characterized by defects in eye, bone and nervous tissue. The generation and characterization of mouse models with defects in plasmalogen levels have significantly advanced our understanding of the role and importance of plasmalogens as well as pathogenetic mechanisms underlying RCDP. A review of the current mouse models and the description of the combined knowledge gathered from the histopathological and biochemical studies is presented and discussed. Further characterization of the role and functions of plasmalogens will contribute to the elucidation of disease pathogenesis in peroxisomal and non-peroxisomal disorders. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of Peroxisomes in Health and Disease.

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