1-Pyrenol: A Biomarker for Occupational Exposure to Polycyclic Aromatic Hydrocarbons

Genotoxic exposures of potroom workers

“…Among the exposed potroom workers in our study, smoking habits did not, however, at all affect the l-hydroxypyrene concentrations in urine. This finding is in accordance with the results of 3 previous studies on aluminum workers (10,11,26), and a study on foundry workers with much lower urinary concentrations of l-hydroxypyrene (3 1).…”

Effect of the reduction of skin contamination on the internal dose of creosote workers exposed to polycyclic aromatic hydrocarbons

“…l-OH-pyrene was used as the biological indicator for internal PAH exposure. This metabol ite of pyrene is increasingly being used and is more and more accepted as a biological indicator of the internal dose of PAH (12)(13)(14)(15)(16). Interviews were conducted by a trained interviewer using a questionnaire about personal characteristics, including age, weight, height, smoking habits, and alcohol consumption.…”

The Gulf Oil Spill

“…In addition, in this work setting (an aluminum production plant), environmental levels of pyrene were strongly correlated with the environmental levels of total PAHs, indicating that pyrene is an appropriate environmental PAH marker in this situation. Thus, 1-Hydroxypyrene levels in urine may be used as a biomarker of exposure to PAHs in certain situations (Tolos et al 1990). Additional studies have evaluated the usefulness of determining PAH or metabolite levels in human urine as a measure of exposure in industrial and environmental exposure settings (Granella and Clonfero 1993;Hansen et al 1993;Herikstad et al 1993;Likhachev et al 1993;Ovrebo et al 1994;Santella et al 1993;Strickland et al 1994;Van Hummelen et al 1993;Van Rooij et al 1993a, 1993bViau et al 1993).…”