Genotoxic exposures of potroom workers

Abstract

The following article refers to this text: 2008;34(6):463-470

Cytochrome P450 (CYP) and glutathione S-transferases (GST) polymorphisms (CYP1A1, CYP1B1, GSTM1, GSTP1 and GSTT1) and urinary levels of 1-hydroxypyrene in Turkish coke oven workers

“…This is in agreement with other studies of coke oven workers (Zhang et al, 2001), iron foundry workers (Carstensen et al, 1999;Alexandrie et al, 2000) and asphalt workers (Burgaz et al, 1998). Similarly, we found that smoking had no significant effect the urinary 1-OHP levels of the control group.…”

“…These findings clearly indicate that the exposure of PAH is rather YP and GST polymorphisms and 1-OHP 515 high in coke oven workers and/or that, in Chinese coke oven workers, the use of protective equipment and proper clothing is poor. The lower levels of 1-OHP found in our study were similar to the mean urinary 1-OHP levels of Swedish aluminum factory workers (Carstensen et al, 1999;Alexandrie et al, 2000), probably explainable by the continuous use of protective equipment and clothing by the workers in our study. However, in our study 16% of urinary 1-OHP levels in coke oven workers still exceeded the occupational exposure limit (OEL) of 2.3 μmol mol -1 of creatinine (Jongeneelen, 2001).…”

“…These results indicate that up to 1/6 of the workers in the coke factory studied have high PAH absorption despite the use of protective equipment, suggesting that individual safety precautions may not be being used effectively by some of the workers studied. On the other hand, the concentration of urinary 1-OHP of control group in our study was lower than that of the Chinese controls (Hanaoka et al, 2002;Leng et al, 2004) but higher than Sweden, Italian and Korean controls (Carstensen et al, 1999;Alexandrie et al, 2000;Yang et al, 2003). The discrepancies observed between the studies could be due to the distinct life style factors of the populations studied, such as smoking habits, passive smoking, diet and heating with coke at home.…”

“…In this study, biological monitoring of the internal PAH dose was done by analysis of urinary 1-OHP which has been suggested as a biomarker of PAH exposure because of the high sensitivity of the analytical method and because it takes into account all exposure routes (Burgaz et al, 1998;Carstensen et al, 1999;Alexandrie et al, 2000). We found that the concentration of urinary 1-OHP of Turkish coke oven workers was significantly higher (about fivefold) than that of the controls.…”

Cancer Risk Assessment, Indicators, and Guidelines for Polycyclic Aromatic Hydrocarbons in the Ambient Air

“…Coke ovens, carbon electrode production plants, tar distillation plants, aluminum smelters, and creosote impregnation plants represent workplaces where high urinary 1-OHP levels are often observed. In a recent biomonitoring study of a Söderberg aluminum reduction plant in Sweden, urine samples from 96 pot-room workers and 5 control subjects were analyzed for 1-OHP (Carstensen et al 1999). Values observed (median, range) were 4.31 (0.09-17.7) µmol/mol creatinine for workers and 0.13 (0.06-0.75) µmol/mol creatinine for controls.…”