10. Moth Sex Pheromone Olfaction: Flux and Flexibility in the Coordinated Confluences of Visual and Olfactory Pathways

Baker, Thomas C.; Hansson, Bill S.

doi:10.1525/9780520964433-011

Cited by 5 publications

(11 citation statements)

References 122 publications

(310 reference statements)

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“…(b) Schematic diagram showing possible connections between olfactory (pheromone) and visual pathways converging in the ΔLP region of the moth protocerebrum. Based on current results and supported by other proposed models (Baker & Hansson, ). Projections from optic lobe neuropils target optic glomeruli in the dorsal regions of posterior ventrolateral protocerebrum (PVLP) and posterior lateral protocerebrum (PLP), overlapping with olfactory outputs from Pl‐v_e(MGC) and Pml_a(MGC) neurons in ΔLP region.…”

Section: Discussionsupporting

confidence: 82%

Moth pheromone‐selective projection neurons with cell bodies in the antennal lobe lateral cluster exhibit diverse morphological and neurophysiological characteristics

Lee

Celestino

Stagg

et al. 2019

J of Comparative Neurology

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Olfactory projection neurons convey information from the insect antennal lobe (AL) to higher brain centers. Previous reports have demonstrated that pheromone-responsive projection neurons with cell bodies in the moth medial cell cluster (mcPNs) predominantly have dendritic arborizations in the sexually dimorphic macroglomerular complex (MGC) and send an axon from the AL to the calyces of the mushroom body (CA) as well as the lateral horn (LH) of the protocerebrum via the medial AL tract. These neurons typically exhibit a narrow odor tuning range related to the restriction of their dendritic arbors within a single glomerulus (uniglomerular). In this study, we report on the diverse physiological and morphological properties of a group of pheromone-responsive olfactory projection neurons with cell bodies in the AL lateral cell cluster (MGC lcPNs) of two closely related moth species. All pheromone-responsive lcPNs appeared to exhibit "basket-like" dendritic arborizations in two MGC compartments and made connections with various protocerebral targets including ventrolateral and superior neuropils via projections primarily through the lateral AL tract and to a lesser extent the mediolateral antennal lobe tract.Physiological characterization of MGC lcPNs also revealed a diversity of response profiles including those either enhanced by or reliant upon presentation of a pheromone blend. These responses manifested themselves as higher maximum firing rates and/or improved temporal resolution of pulsatile stimuli. MGC lcPNs therefore participate in conveying diverse olfactory information relating to qualitative and temporal facets of the pheromone stimulus to a more expansive number of protocerebral targets than their mcPN counterparts. K E Y W O R D S Heliothis, insect, olfaction, pheromone, RRID:AB_2307336, RRID:SCR_010279, RRID: SCR_014344, subflexa, virescens 1 | INTRODUCTION Olfactory sensory neurons (OSNs) located in cuticular hairs covering insect antennae, called sensilla, project axons into the brain and form arbors restricted to olfactory glomeruli in the antennal lobe (AL) (Hildebrand, 1996). OSNs form synaptic connections in the AL with local interneurons (LNs) and projection neurons (PNs) that relay olfactory information from the AL to the protocerebrum. In the large sphingid hawkmoth, Manduca sexta, initial studies revealed three primary AL cell clusters and their relationships to three main projection tracts connecting the AL to the protocerebrum. PNs with somata in the medial and anterior cell clusters were associated with only the dorsal root of the medial antennal lobe tract (mALT), whereas PNs with cell bodies in the lateral cluster projected through the mALT (ventral root), mediolateral ALT (mlALT), and lateral ALT (lALT) Seong-Gyu Lee and Christine Fogarty Celestino authors contributed equally to this work.

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Section: Discussionsupporting

confidence: 82%

Moth pheromone‐selective projection neurons with cell bodies in the antennal lobe lateral cluster exhibit diverse morphological and neurophysiological characteristics

Lee

Celestino

Stagg

et al. 2019

J of Comparative Neurology

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“…Schematic diagram showing a suggested relationship between olfactory (pheromone) and visual pathways converging in the ∆LP region of the moth protocerebrum. Based on current results and supported by other proposed models (Baker and Hansson, 2016). Projections from optic lobe neuropils target optic glomeruli in the dorsal regions of PVLP and PLP, overlapping with olfactory v-lALT MGC lcPNs.…”

Section: Figuresupporting

confidence: 84%

“…While some neurons were activated by single odorants primarily the main pheromone component (Z11-16:Ald), in many cases responses were improved by stimulation with a behaviorally relevant pheromone blend. Based on limited data, Baker and Hansson (2016) proposed that the ml-and l-ALT pathways relayed 'chromatic' information (i.e. activity dependent on presence of a behaviorally active pheromone blend) to the lateral protocerebrum but suggested that these neurons exhibited poor temporal resolution of pusatile stimuli.…”

Section: Discussionmentioning

confidence: 99%

“…The area encompassed by ∆LP includes small superior-most parts of PVLP and PLPboth areas reported to contain optic glomeruli that receive visual input from the lobula plate of the optic lobe (Ito et al, 2014;). Baker and Hansson (2016) proposed that ∆LP could be an important neural substrate for multimodal integration of olfactory and visual information critical to pheromone-mediated optomotor anemotaxis. Furthermore, connections within SIP suggest another possible site for multimodal visual/olfactory convergence.…”

Section: Discussionmentioning

confidence: 99%

“…Based on previous reports of lcPNs, Baker and Hansson (2016) proposed that lcPNs are 'chromatic' with respect to central processing in that they convey information to the protocerebrum about the presence of a pheromone blend. They advanced that chromatic PNs had poorer temporal resolution of pulsatile stimuli compared to m-mcPNs and postulated a role in activating circuits that drive longer-lasting moth flight behaviors such as counterturning.…”

Section: Introductionmentioning

confidence: 99%

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Olfactory Projection Neurons From the Moth Antennal Lobe Lateral Cluster exhibit Diverse Morphological and Neurophysiological Characteristics

Stagg

et al. 2018

Preprint

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Olfactory projection neurons convey information from the insect antennal lobe (AL) to higher centers in the brain. Many studies on moths have reported excitatory projection neurons with cell bodies in the medial cell cluster (mcPNs) that predominantly send an axon from the AL to calyces of the mushroom body (CA) via the medial antennal lobe tract (mALT) and then to the lateral horn (LH) of the protocerebrum. These neurons tend to have dendritic arbors restricted to a single glomerulus (i.e. they are uniglomerular). In this study, we report on the physiological and morphological properties of a group of pheromone-responsive olfactory projection neurons with cell bodies in the moth AL lateral cell cluster (lcPNs) of two heliothine moth species. While mcPNs typically exhibit a narrow odor tuning range related to the restriction of their dendritic arbors within a single glomerulus, lcPNs exhibited an array of morphological and physiological configurations. Pheromone-responsive lcPNs varied in their associations with glomeruli (uniglomerular and multiglomerular), dendritic arborization structure and connections to higher brain centers with projections primarily through the lateral antennal lobe tract and to a lesser extent the mediolateral antennal lobe tract to a variety of protocerebral targets including ventrolateral and superior neuropils as well as LH. Physiological characterization of lcPNs also revealed a diversity of response profiles including those either enhanced by or reliant upon presentation of a pheromone blend. These responses manifested themselves as higher maximum firing rates and/or improved temporal resolution of pulsatile stimuli. lcPNs therefore participate in conveying a variety of olfactory information relating to qualitative and temporal facets of the pheromone stimulus to a more expansive number of protocerebral targets than their mcPN counterparts. The role of lcPNs in the overall scheme of olfactory processing is discussed.

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Distinct protocerebral neuropils associated with attractive and aversive female-produced odorants in the male moth brain

Kymre

Liu

Ian

et al. 2020

Preprint

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The pheromone system of heliothine moths is an optimal model for studying principles underlying higher-order olfactory processing. In Helicoverpa armigera, three male-specific glomeruli receive input about three female-produced signals, the primary pheromone component, serving as an attractant, and two minor constituents, serving a dual function, i.e. attraction versus inhibition of attraction. From the antennal-lobe glomeruli, the information is conveyed to higher olfactory centers, including the lateral protocerebrum, via three main paths – of which the medial tract is the most prominent. In this study, we traced physiologically identified medial-tract projection neurons from each of the three male-specific glomeruli with the aim of mapping their terminal branches in the lateral protocerebrum. Our data suggest that the neurons’ wide-spread projections are organized according to behavioral significance, including a spatial separation of signals representing attraction versus inhibition – however, with a unique capacity of switching behavioral consequence based on the amount of the minor components.

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10. Moth Sex Pheromone Olfaction: Flux and Flexibility in the Coordinated Confluences of Visual and Olfactory Pathways

Cited by 5 publications

References 122 publications

Moth pheromone‐selective projection neurons with cell bodies in the antennal lobe lateral cluster exhibit diverse morphological and neurophysiological characteristics

Moth pheromone‐selective projection neurons with cell bodies in the antennal lobe lateral cluster exhibit diverse morphological and neurophysiological characteristics

Olfactory Projection Neurons From the Moth Antennal Lobe Lateral Cluster exhibit Diverse Morphological and Neurophysiological Characteristics

Distinct protocerebral neuropils associated with attractive and aversive female-produced odorants in the male moth brain

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