100 YEARS OF VITAMIN D: Supraphysiological doses of vitamin D changes brainwave activity patterns in rats

Lima, Gabriella Oliveira; Silva, Alex Luiz Menezes da; Azevedo, Julianne Elba Cunha; Nascimento, Chirlene Pinheiro; Vieira, Luana Rodrigues; Hamoy, Akira Otake; Ferreira, L.; Bahia, Verônica Regina Lobato Oliveira; Muto, Nilton Akio; Lopes, Dielly Catrina Favacho; Hamoy, Moisés

doi:10.1530/ec-21-0457

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…Hypervitaminosis D always results in hypercalcaemia, which may be toxic to brain function. Animal studies showed that high cholecalciferol intake, 25,000 IU/kg, for four consecutive days reduces brainwave activity [ 186 ]. Senescence-accelerated-mouse-phenotype (SAMP) strain-8 mice, an animal model of accelerated human ageing, showed a progressive increase in serum 25OHD 3 , which coexists with reduced cognitive function and increased capillary permeability [ 187 ].…”

Section: Hypervitaminosis D and Adverse Cns Outcomesmentioning

confidence: 99%

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Cui

Eyles

2022

Nutrients

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Twenty of the last one hundred years of vitamin D research have involved investigations of the brain as a target organ for this hormone. Our group was one of the first to investigate brain outcomes resulting from primarily restricting dietary vitamin D during brain development. With the advent of new molecular and neurochemical techniques in neuroscience, there has been increasing interest in the potential neuroprotective actions of vitamin D in response to a variety of adverse exposures and how this hormone could affect brain development and function. Rather than provide an exhaustive summary of this data and a listing of neurological or psychiatric conditions that vitamin D deficiency has been associated with, here, we provide an update on the actions of this vitamin in the brain and cellular processes vitamin D may be targeting in psychiatry and neurology.

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Section: Hypervitaminosis D and Adverse Cns Outcomesmentioning

confidence: 99%

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Cui

Eyles

2022

Nutrients

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“…Interestingly, high levels of vitamin D can cause hypercalcemia and may affect neuronal function. Animal models with high vitamin D intake or increase in the active form of circulating vitamin D by various genetic manipulation have been shown to be associated with reduced brainwave activity, impaired cognitive function, and premature aging [187][188][189]. Hence, precautionary measures should be considered during future clinical trials to assess efficacy and safety of vitamin D supplementation in AD patients.…”

Section: Vitamin Dmentioning

confidence: 99%

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

et al. 2023

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Alzheimer’s disease (AD) is the most common type of dementia that affects millions of individuals worldwide. It is an irreversible neurodegenerative disorder that is characterized by memory loss, impaired learning and thinking, and difficulty in performing regular daily activities. Despite nearly two decades of collective efforts to develop novel medications that can prevent or halt the disease progression, we remain faced with only a few options with limited effectiveness. There has been a recent growth of interest in the role of nutrition in brain health as we begin to gain a better understanding of what and how nutrients affect hormonal and neural actions that not only can lead to typical cardiovascular or metabolic diseases but also an array of neurological and psychiatric disorders. Vitamins and minerals, also known as micronutrients, are elements that are indispensable for functions including nutrient metabolism, immune surveillance, cell development, neurotransmission, and antioxidant and anti-inflammatory properties. In this review, we provide an overview on some of the most common vitamins and minerals and discuss what current studies have revealed on the link between these essential micronutrients and cognitive performance or AD.

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“…На сьогодні вивчення ролі вітаміну D під час вагітності та її наслідків є актуальною та поширеною проблемою. Серед вагітних жінок поширеність дефіциту та недостатності вітаміну D досить висока і становить від 35% до 80% [11].…”

Section: вступunclassified

Role of vitamin D in the genesis of recurrent reproductive loss

Poladich,

Kostenko

2023

UJHW

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Currently, there is active discussion worldwide regarding the impact of vitamin D deficiency and the manifestations of its immunosuppressive properties on the development of recurrent pregnancy loss. Vitamin D deficiency and insufficiency are quite common, with prevalence ranging from 35% to 80%. Despite modern molecular-genetic technologies, the question of polymorphisms in the vitamin D receptor (VDR) genes remains relevant. Purpose - analysis of the relationship between VDR genes polymorphisms in women affected by recurrent reproductive loss. A systematic search of published literature with a meta-analysis was conducted using the PubMed, Web of Science, and Scopus databases for the period from 2021 to 2022. This review examines the association VDR in women with recurrent reproductive losses. There is a connection between low vitamin D levels and the risk of developing various somatic diseases. The review of scientific data confirmed information about the comorbidity of diseases related to vitamin D deficiency or insufficiency. Thus, extragenital pathology creates unfavorable conditions for recurrent pregnancy losses, limits adaptive mechanisms, and contributes to the exacerbation of complications that may arise due to vitamin D deficiency or insufficiency. During the review, it was found that the most prevalent and well-studied polymorphic variants of the VDR gene, such as FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), and Cdx2, are associated with various diseases, including reproductive losses. In particular, the FokI polymorphism (rs2228570) of the VDR gene acts as an independent factor capable of predicting the level of vitamin D in the blood, influencing pregnancy outcomes. Conclusions. The obtained data represent significant information for assessing the risk of recurrent reproductive losses and developing new strategies for the prevention and treatment of these conditions. No conflict of interests was declared by the authors.

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100 YEARS OF VITAMIN D: Supraphysiological doses of vitamin D changes brainwave activity patterns in rats

Cited by 4 publications

References 47 publications

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

Role of vitamin D in the genesis of recurrent reproductive loss

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