1087 Qigong Exercise Improved Quality of Sleep and Reduced Interleukin-1 Beta and Interleukin-6 Among Persons With Depressive Symptoms and Sleep Disturbances: A randomized Controlled Trial

Abstract

Introduction:Menopause has been associated with elevated risk of mood disturbances. This relationship has been attributed to a number of factors including alterations in hormone levels, psychosocial factors, and insomnia associated with menopause. While cognitive behavioral therapy for insomnia (CBT-I) has been shown to also reduce depression in the general population, the effectiveness of CBT-I in reducing depression associated with menopause has not been tested. Methods: 122 females with insomnia concurrent with menopause were randomized into three conditions: CBT-I (N=41), Sleep Restriction Therapy (SRT, N=41) and an Information-only control condition (IC, N=40). Outcome measures included Insomnia Severity Index (ISI), and Beck Depression Inventory (BDI-II; sans sleep items). All measures were conducted pre-, post-treatments, and at 6 months follow-up. Results: dCBT-I resulted in a robust significant improvement in ISI (-8.2 ± 5.3 points) compared to control (-4.0 ± 4.2 points). The post-treatment remission rate (ISI≤10) was significantly greater in the dCBT-I condition (67.1%) compared to the control group (33.7%; p<.01). Similar results were observed for depression symptoms, with the dCBT-I condition exhibiting decreased depression severity (-3.0 ± 4.1 points, from 7.2 ± 4.2 pre-treatment) compared to the control condition (-1.2 ± 3.2 points, from 7.1 ± 3.9 pre-treatment, p<.01). Whereas depression rates (QIDS≥10) were comparable between conditions at pre-treatment (control: 28.3%; dCBT-I: 24.0%, p>.05), the dCBT-I condition exhibited a significantly lower rate of clinically significant depression at post-treatment (8.2%) compared to the control group (19.0%, p<.01). Results stratified by demographics indicated that dCBT-I yielded a near identical and significant decrease in both insomnia and depression symptom severity across all demographic groups. Conclusion: Findings from this study provide evidence for the effectiveness of CBT-I for insomnia associated with menopause, and also suggest its potential for reducing concurrent depression. Furthermore, gains in depression symptoms appear to be sustained up to 6 months following CBT-I, and may also continue to decrease over time.

Insomnia and Depressive Symptoms in Adolescents: Can Cognitive Behavioral Therapy for Insomnia Contribute to Improve Adolescents’ Depressive Symptoms?

“…Another possible mechanism is related to inflammatory bio-markers. Sleep disturbance is associated with increased levels of inflammatory markers such as interleukin-1 beta and interleukin-6 in individuals with depression [52]. Treatment of insomnia using behavioral interventions leads to reductions in inflammatory markers [53].…”

Mindfulness, qigong y su impacto en la salud

“…Otras evidencias señalan que la práctica del qigong contribuye a la prevención del cáncer, ya que el ejercicio físico es un factor clave en el estilo de vida, además de potenciar el sistema inmune y mediar sobre la respuesta inflamatoria (Cheung et al, 2005;Oh et al, 2012). Disminuye la depresión y mejora la calidad del sueño (Larkey et al, 2015;Chan et al, 2017), y reduce la hipertensión arterial (Ospina et al, 2017;Lee, Lim y Lee, 2004). Mejora la calidad de vida en pacientes con cáncer (Stenlund, Lindstrom, Granlund y Burell, 2005;Pippa et al, 2007) y en pacientes con trastornos cardiovasculares (Hui, Wan, Chan y Yung, 2006;Johansson et al, 2011).…”

“…Se han probado los efectos beneficiosos del qigong sobre la presión arterial y los niveles de lípidos sanguíneos (Wang et al, 2010), así como efectos positivos en la salud, la vitalidad y una mente tranquila (Asmaee et al, 2012). Reduce el estrés en los empleados de un hospital (Bazarko et al, 2013), ralentiza el envejecimiento (Cheong y Lee, 2014), otorga mayor percepción de bienestar psicológico (Cheung et al, 2015), aumento de la densidad ósea y menos caídas en los adultos (Chan et al, 2017). Mejora la función cognitiva (Choi y Koh, 2015), aumenta el bienestar en escolares (Jennings et al, 2013), y favorece la función pulmonar en niños asmáticos (Chu, 2010).…”

“…Es el arte y la ciencia de la salud que utiliza técnicas de respiración, movimientos suaves y meditación para fortalecer y hacer circular el qi (energía vital). La práctica regular conduce a una mejor salud, vitalidad y una mente tranquila, sosegada y en paz (Wang, Wang, Fan, Sedas y Wang, 2017;Chan et al, 2017;Larkey et al, 2015).…”

Peer Review #1 of "Exercise can improve sleep quality: a systematic review and meta-analysis (v0.1)"

“…1). We included 17 293 trials in the qualitative synthesis and detected seven unpublished trials and one completed trial 294 without outcomes data (Chan et al, 2017). Ultimately, 557 participants in nine trials were 295 included in the quantitative synthesis.…”