1091 Intracellular Expression of Interleukin-10 (IL-10) in Patients With Ovarian Cancer

Rogala, E.; Nowicka, Aldona; Wertel, Iwona; Piekarczyk, Wanda; Zakrzewski, Maciej; Kotarski, J

doi:10.1016/s0959-8049(12)71696-9

Cited by 3 publications

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“…Th17 and Tc17 cells have obtained an increasing amount of attention owing to their roles in tumorigenesis; their levels, as well as IL-17 production, are upregulated in the peripheral blood of patients with cancer (19,26,27). Similarly, results from the present study revealed significant increases in the number of Th17 and Tc17 cells in the peripheral blood of patients with DTC.…”

supporting

confidence: 73%

Effects of iodine-131 radiotherapy on Th17/Tc17 and Treg/Th17 cells of patients with differentiated thyroid carcinoma

Zhang

Chen

et al. 2017

Exp Ther Med

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Abstract. T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells serve important roles in a number of inflammatory and autoimmune diseases. The aim of the present study was to examine the distribution of Th17, Tc17 and Treg cells in patients with differentiated thyroid cancer (DTC) prior to as well as 7, 30 and 90 days following radioactive iodine-131 ( 131 I) therapy, and to elucidate the probable effects of 131 I therapy on Th17/Tc17 and Treg/Th17 cells in patients with DTC. A total of 40 patients with DTC (26 female; 14 male) between the ages of 24 and 72 years, as well as 13 age-and sex-matched healthy subjects were included in this study. The number of Th17, Tc17 and Treg cells in the peripheral blood of patients with DTC and of healthy Controls were assessed by flow cytometry. Th17 and Tc17 cells were counted as percentages of the number of CD3 + T cells; Treg cells were counted as a percentage of the number of CD4 +

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confidence: 73%

Effects of iodine-131 radiotherapy on Th17/Tc17 and Treg/Th17 cells of patients with differentiated thyroid carcinoma

Zhang

Chen

et al. 2017

Exp Ther Med

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“…Similar results were presented by Rogala et al . [ 22 ] in patients with ovarian cancer. They detected increased levels of IL-17 and lymphocytes CD4+ in the peripheral blood, peritoneal fluid and cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Expression of Th17 cell population regulatory cytokines in laryngeal carcinoma – Preliminary study

Kopta¹,

Mochocki²,

Morawski³

et al. 2015

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Aim of the studyAim of the study was to evaluate the potential role of regulatory and proinflammatory cytokines IL-23 and IL-17 as Th17 lymphocyte activity markers in relation to invasiveness in laryngeal cancer.Material and methodsThe immunological analysis was conducted in 50 patients treated for squamous cell laryngeal carcinoma and 30 healthy volunteers as controls. The levels of IL-23 and IL-17 in supernatants of purified peripheral blood mononuclear cell cultures were determined by using the enzyme-linked immunosorbent assay (ELISA). The clinicomorphological criteria included pTNM, stage, G, and the total tumour front grading (TFG) score.ResultsOur data demonstrated higher concentrations of IL-23 in patients as compared to controls (p = 0.0001). No statistical difference for IL-17 in these groups was observed. Our study revealed significant dependences in IL-23 expression on pT (p = 0.04), histological differentiation (p = 0.04), and TFG total score (p = 0.02). Advanced tumours (pT3–pT4) with higher grade (G2–G3) and higher invasiveness (> 14 TFG points) were characterised by elevated IL-23 levels in PBMC supernatants. Our data did not indicate a relationship between cytokine levels and three- and five-year survival. However, a tendency towards lower content of IL-23 in PBMC cultures in patients who lived longer than five years after treatment was noted. The relationships between IL-17 level in PBMC cultures and clinicomorphological and prognostic parameters have not been disclosed.ConclusionsThe results of this study suggest the importance of regulatory cytokine IL-23 in determining the aggressive potential of laryngeal carcinomas.

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“…Multiple studies indicated that marked levels of IL-17 mRNA and protein were present in patients with various malignancies, including ovarian cancer (Kato et al, 2001;Rogala et al, 2012), breast cancer (Nam et al, 2008;Zhu et al, 2008;Yang et al, 2012), non-small-cell lung cancer (Liu et al, 2012;Zhang et al, 2012c;He et al, 2013b), renal cell carcinoma (Inozume et al, 2009), lung adenocarcinoma , small-cell lung cancer He et al, 2013a), laryngeal squamous cell carcinoma (Meng et al, 2012a), non-small-cell lung carcinoma (Kirshberg et al, 2011), prostate cancer (Haudenschild et al, 2002), Sezary syndrome (Cirée et al, 2004), multiple myeloma (Prabhala et al, 2010;Dong et al, 2012;Lemancewicz et al, 2012;Zhang et al, 2012c), pancreatic cancer (Kuang et al, 2010;He et al, 2011), colorectal carcinoma (Le Gouvello et al, 2008;Radosavljevic et al, 2010;Cui et al, 2012), breast cancer (Lyon et al, 2008), and gastric carcinoma (Zhang et al, 2008a;Meng et al, 2012b). In addition, considerable proportions of IL-17 were observed in subjects with malignant pleural effusions (Klimatsidas et al, 2012;Xu et al, 2013) and bladder carcinoma (Doroudchi et al, 2013).…”

Section: Il-17 Levels In Cancer Patientsmentioning

confidence: 99%

Interleukin-17 Superfamily and Cancer

Yuzhalin¹,

Kutikhin²

2015

Interleukins in Cancer Biology

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1091 Intracellular Expression of Interleukin-10 (IL-10) in Patients With Ovarian Cancer

Cited by 3 publications

References 0 publications

Effects of iodine-131 radiotherapy on Th17/Tc17 and Treg/Th17 cells of patients with differentiated thyroid carcinoma

Effects of iodine-131 radiotherapy on Th17/Tc17 and Treg/Th17 cells of patients with differentiated thyroid carcinoma

Expression of Th17 cell population regulatory cytokines in laryngeal carcinoma – Preliminary study

Interleukin-17 Superfamily and Cancer

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