11 Oxidation of Amines and N-Hetarenes

Abstract

The oxidation of amines and hetarenes are significant transformations that have been widely applied in synthetic organic chemistry. In this chapter, the oxidation of primary, secondary, and tertiary amines, affording imines, nitriles, amides, carbonyls, oximes, nitro compounds, diazenes and their oxides, nitrones, hydrazines, and N-oxides, as well as the oxidation of hetarenes including pyridines, azoles, pyrroles, indoles, guanines, and adenines, are comprehensively discussed. In addition to traditional organometallic catalysis to fulfill these oxidation reactions, some advanced approaches such as photocatalysis, biochemical catalysis, and biomimetic catalysis are also described.

Recent advances in catalytic silylation of hydroxyl‐bearing compounds: A green technique for protection of alcohols using Si–O bond formations

“…[96][97][98][99] Due to the N-O bond polarization, one can classify the heteroaromatic N-oxides properties as strong Lewis bases. [100][101][102][103] In this regard, those Lewis base catalysts which possess the pyridine oxide moiety-positioned in a chiral environment-have constituted a specific type of active catalysts. Moreover, commonly under mild reaction conditions, the mentioned catalysts are capable of high asymmetric induction.…”