11-(Pyridinylphenyl)steroids—A new class of mixed-profile progesterone agonists/antagonists

Scope of the Suzuki−Miyaura Cross-Coupling Reactions of Potassium Heteroaryltrifluoroborates

“…Even though the first synthesis of quinolin-3-ylboronic acid dates back to 1959,3 only a few examples have been reported in the literature of their incorporation into an organic molecule by means of the Suzuki-Miyaura cross-coupling reaction 11a,41…”

Selective progesterone receptor modulators in reproductive medicine: pharmacology, clinical efficacy and safety

“…More recently, a class of SPRMs, called mixed-profile progestogens, has been described. These compounds are reported to have more agonistic activity than the currently described SPRMs (40).…”

A Bifunctional Reagent Designed for the Mild, Nucleophilic Functionalization of Pyridines

“…To demonstrate the application of this method in the context of late-stage functionalization, the direct cyanation was carried out on 1w , a mixed progesterone agonist/antagonist (Scheme ). This compound contains two electrophilic ketones: one bearing an epimerizable stereocenter, the other conjugated to a diene. Of particular note, these functionalities are reactive toward the oxidants used to form pyridine N -oxides, as well as typical radicals used in Minisci-type reactions .…”