11C-Methionine-PET for Evaluation of Carbon Ion Radiotherapy in Patients with Pelvic Recurrence of Rectal Cancer

Abstract

11C-methionine-PET can be used for early prediction of local re-recurrence after CIRT. Because CIRT is local therapy, (11)C-methionine-PET cannot predict distant metastasis or survival after CIRT.

[11C]Gefitinib ([11C]Iressa): Radiosynthesis, In Vitro Uptake, and In Vivo Imaging of Intact Murine Fibrosarcoma

“…In our institute, carbon-ion radiotherapy (CIRT) using a carbon-ion beam was started in 1994, and more than 3,000 patients suffering from malignant diseases, including NSCLC, have been treated by CIRT [17][18][19]. PET with [ 11 C]methionine has been used to monitor the response of CIRT in patients with bone and soft tissue sarcoma and rectal cancer [20,21].…”

A Study on the Prognostic Evaluation of Carbon Ion Radiotherapy for Head and Neck Adenocarcinoma with C-11 Methionine PET

“…In this study, in order to evaluate CIRT, we prospectively used L-methyl [11C]-methionine (MET)-positron emission tomography (PET). In our hospital, similar studies have been conducted in the past for bone and soft tissue sarcoma, chordoma, and recurrent cases of colon cancer [6][7][8]. Furthermore, in cases of bone and soft tissue sarcoma and chordoma, we previously reported that it was possible to predict local recurrence based on a decreasing rate of accumulation before and after heavy particle radiotherapy [6,8].…”

“…In our hospital, similar studies have been conducted in the past for bone and soft tissue sarcoma, chordoma, and recurrent cases of colon cancer [6][7][8]. Furthermore, in cases of bone and soft tissue sarcoma and chordoma, we previously reported that it was possible to predict local recurrence based on a decreasing rate of accumulation before and after heavy particle radiotherapy [6,8]. In addition, in cases of choroidal melanoma, no great changes in tumor size were observed in magnetic resonance imaging (MRI), but a decrease in the concentration of MET was observed from 6 months after the completion of CIRT, thus making it possible to determine the effects [9].…”

“…administration of 740 MBq (mean, 702.2± 75.4 MBq; range, 374-870 MBq) of MET. Regarding the difference of sensitivity in PET scanners, static emission scans were performed for 30 min in ECAT EXACT HR+ and 15 min in ECAT EXACT 47 for each bed position, respectively [6][7][8].…”

Usefulness of 11C-methionine positron emission tomography for detecting intracranial ameloblastic carcinoma: A case report

“…As protein synthesis is upregulated in tumor cells compared with that observed in the central nervous system, methionine PET is useful for visualizing the clear border of intracranial malignant lesions in cases of glioma (25). In addition, a positive association has been reported between the efficiency of methionine accumulation and the MIB-1 index, an indicator of the proliferation of malignancy, in the setting of rectal cancer metastasis (26). In previous studies, FDG-PET has been described as a diagnostic tool for detecting ameloblastic carcinoma (17–19).…”