12 Month Follow-Up of Mebendazole Therapy for Onchocerciasis

Rivas-Alcala, A.R.; Greene, BruceM.; Taylor, Hugh R.; Domiguez-Vaques, A.; Ruvalcaba-Macias, A.M.; Lugo-Pfeiffer, C.; Beltrán-Hernández, F.

doi:10.1016/s0140-6736(81)91235-6

Cited by 10 publications

(2 citation statements)

References 3 publications

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“…These have been suramin (Van Hoofed al. 1947), diethylcarbamazine (Santiago-Stevenson, Oliver-Gonzalez & Hewitt, 1947), levamisole (O'Holohan & Zaman, 1974), mebendazole (Rivas-Alcala et al 1981) and, most recently, ivermectin (Greene et al 1985;Jenkins, 1990). For each of these drugs the mode of action against filarial worms remains uncertain, although there are many contending propositions (Subrahmanyam, 1987).…”

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confidence: 99%

Diethylcarbamazine (DEC): immunopharmacological interactions of an anti-filarial drug

Maizels¹,

Denham

1992

Parasitology

134

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Anti-parasitic drugs may achieve their therapeutic effect either by direct activity against the pathogenic organism, or by altering host factors which lead to parasite killing. In this review, we discuss the evidence for an indirect mode of action for one major anti-filarial drug, diethylcarbamazine (DEC). The interpretation most consistent with existing data is that DEC alters arachidonic acid metabolism in microfilariae and in host endothelial cells. These changes may result in vasoconstriction and amplified endothelial adhesion leading to immobilization of microfilarial parasites, enhanced adherence and cytotoxic activity by host platelets and granulocytes. These events would represent activation of the innate, non-specific immune system, independent of the adaptive, antigen-specific, immune response. This model explains the paradox between rapid clearance in vivo and the lack of an in vitro effect, as well as the efficacy of DEC in non-immune animals. It may also account for the inconsistencies in the effects of DEC against different filariae in different host species. In addition, we discuss the significant side-effects often associated with treatment of heavily infected patients, and the longer-term changes in T-cell reactivity and the host-parasite relationship which follow successful treatment with DEC.

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confidence: 99%

Diethylcarbamazine (DEC): immunopharmacological interactions of an anti-filarial drug

Maizels¹,

Denham

1992

Parasitology

134

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“…Flubendazole and mebendazole are active on third and fourth stages of different filarial species (Burbure et al, 1986 ;Katiyar et al, 1987), as well as embryonic stages of O. volvulus (Rivas Alcala et al, 1981 a, b). However, they are poorly absorbed orally.…”

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confidence: 99%

Activity of albendazole-ivermectin combination and other filaricidal drugs against infective larvae, preadult, microfilariae and adult worms ofMolinema dessetaein the rodentProechimys oris.

1994

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Summary :The efficacy of albendazole-ivermectin combination was tes ted on adult and developing stages of Molinema dessetae in the rodent Proechimys oris. Albendazole and ivermectin, both given alone, suramin and diethylcarbamazine were used as reference compounds. The drug combination (albendazole at 10 mg/kg/ day x 5 days and Ivermectin at 0.04 mg/kg/day x 5 days) was effective against infective larvae and preadult worms, and substan tially reduced the number of live adult worms. The known filaricidal agents, diethylcarbamazine (400 mg/kg twice daily x 5 days), ivermectin (0.2 mg/kg/day x 5 days), and suramin (40 mg/kg/day x 5 days), as well as albendazole (50 mg/kg/day x 5 days) were active on infective larvae, preadult worms, microfi lariae and adult worms. All drugs had the same level of efficacity on infective larvae. Albendazole had the highest efficacy against adult and preadult worms and diethylcarbamazine was the most active on microfilariae. Although the drug combination was not as effective against preadult and adult worms as albendazole alone, the results indicate that albendazole-ivermectin combination at a low dose had prophylactic effect and suggest a possible macrofilaricidal activity.

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Treatment of Dipetalonema perstans infections with mebendazole

Wahlgren

Frolov

1983

Transactions of the Royal Society of Tropical Medicine and Hygi

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12 Month Follow-Up of Mebendazole Therapy for Onchocerciasis

Cited by 10 publications

References 3 publications

Diethylcarbamazine (DEC): immunopharmacological interactions of an anti-filarial drug

Diethylcarbamazine (DEC): immunopharmacological interactions of an anti-filarial drug

Activity of albendazole-ivermectin combination and other filaricidal drugs against infective larvae, preadult, microfilariae and adult worms ofMolinema dessetaein the rodentProechimys oris.

Treatment of Dipetalonema perstans infections with mebendazole

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