121 Assessment of autonomic dysfunction in patients with primary Sjogren's syndrome: relation to clinical aspect and immunological profiles

Elolemy, Gehan; Rashidi, Abdulrahman Al; Aboughanima, Ahmed; Youssry, Doaa

doi:10.1093/rheumatology/key075.345

Cited by 2 publications

(4 citation statements)

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“…They found higher prevalence of Raynaud’s phenomenon (p=0.048) and higher ESSPRI fatigue scores (p=0.024) in the autonomic dysfunction group ( 6 ). The association of Raynaud’s and autonomic dysfunction is consistent with another study ( 41 ).…”

Section: Autonomic Dysfunction Disease Activity and Symptomatology In Psssupporting

confidence: 92%

“…Similar findings have been reported elsewhere between COMPASS and ESSPRI ( 30 ), ESSDAI ( 41 ) and anxiety ( 42 ). ESSPRI is made up of three components: fatigue, pain and dryness.…”

Section: Autonomic Dysfunction Disease Activity and Symptomatology In Psssupporting

confidence: 91%

“…The association between fatigue and autonomic dysfunction also deserve more investigations. Fatigue is often described as the most disabling symptom of pSS ( 3 , 60 ) and has been shown elsewhere to be associated with autonomic dysfunction using multiple measuring tools in pSS ( 27 , 28 , 30 , 41 , 42 ) and other conditions such as chronic fatigue syndrome and PBC ( 61 ). The biological basis for fatigue is still unclear in pSS but immune dysregulation have been suggested ( 62 , 63 ).…”

Section: Discussionmentioning

confidence: 99%

“…Considering the contribution of the secretomotor domain of COMPASS to the COMPASS total score, the correlation between ESSPRI may be expected driven by the dryness domain. Interestingly, pain and fatigue individually were better predictors than dryness for COMPASS total score ( 5 , 41 ). Tarn et al.…”

Section: Autonomic Dysfunction Disease Activity and Symptomatology In Pssmentioning

confidence: 99%

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Autonomic Nervous System Dysfunction in Primary Sjögren’s Syndrome

Davies

2021

Front. Immunol.

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Primary Sjögren’s syndrome (pSS) is an autoimmune disease which primarily affects the exocrine glands, but can also affect other organs, including the nervous system. Many studies have reported evidence of autonomic nervous system (ANS) dysfunction in pSS which may contribute to a wide range of symptoms and functional burden. Symptoms of ANS dysfunction are common and widespread among patients with pSS and are associated with other features of the disease, particularly fatigue. Accumulating data on the inter-relationship between the ANS and the immune system via the vagus nerve have been reported. Vagus nerve stimulation (VNS) has also been associated with improvement in fatigue in patients with pSS. Taken together, these data suggest that the ANS may be a potential treatment target for pSS, in particularly those with fatigue being a predominant symptom. Future research to dissect the link between the ANS, immune dysregulation and clinical manifestations in pSS and to evaluate the potential of VNS as a therapy for pSS is warranted.

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Section: Autonomic Dysfunction Disease Activity and Symptomatology In Psssupporting

confidence: 92%

“…Similar findings have been reported elsewhere between COMPASS and ESSPRI ( 30 ), ESSDAI ( 41 ) and anxiety ( 42 ). ESSPRI is made up of three components: fatigue, pain and dryness.…”

Section: Autonomic Dysfunction Disease Activity and Symptomatology In Psssupporting

confidence: 91%