Incorporation of aerobic exercises into conventional rehabilitation programs of early stroke patients may provide positive contributions, particularly to mood and aerobic capacity.

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Aim To determine the factors associated with colchicine resistance and the effect of colchicine resistance on health‐related quality of life (QoL) in patients with familial Mediterranean fever (FMF). Methods Demographic and clinical features, MEFV gene mutations, and Pras disease severity scores were recorded. QoL was assessed using the Short Form‐36 (SF‐36) and FMF‐QoL scales. Colchicine resistance was defined as at least 1 attack per month for 6 months at the maximum tolerated dose of colchicine in fully compliant patients. Results The mean age of 118 patients (90 female, 28 male) with FMF was 38.4 ± 12.5 years. The percentage of colchicine‐resistant patients was 19.5%. In univariable analysis, smoking (odds ratio [OR] = 2.885; 95% confidence interval [CI] = 1.104–7.539; P = 0.031), attack duration (OR = 1.955; 95% CI = 1.137–3.360; P = 0.015), presence of arthritis (OR = 5.235; 95% CI = 1.508–18.179; P = 0.009), and disease severity score (OR = 1.790; 95% CI = 1.334–2.402; P < 0.001) were associated with colchicine resistance. The FMF‐QoL and subscales of SF‐36 except for role emotional and vitality, were different between colchicine‐resistant and non‐resistant patients (P < 0.05). Conclusion Smoking, attack duration, presence of arthritis, and disease severity were associated with colchicine resistance in fully compliant FMF patients. Colchicine‐resistant patients had poorer health‐related QoL.

Poly(L-lactic acid) (PLLA) films with different crystallinities were prepared by solvent casting and subsequently annealed at various temperatures (T a ) (80-110 C). The effects of crystallinity on enzymatic degradation of PLLA films were examined in the presence of proteinase K at 37 C by means of weight loss, DSC, FTIR spectroscopy, and optical microscopy. DSC and the absorbance ratio of 921 and 956 cm À1 (A 921 /A 956 ) were used to evaluate crystallinity changes during thermally induced crystallization and enzymatic hydrolysis. The highest percentage of weight loss was observed for the film with the lowest initial crystallinity and the lowest percentage of weight loss was observed for the film with highest crystallinity. FTIR investigation of degraded films showed a band at 922 cm À1 and no band at 908 cm À1 suggested that all degraded samples form a crystals. The rate of degradation was found to depend on the initial crystallinity of PLLA film and shown that enzymatic degradation kinetics followed first-order kinetics for a given enzyme concentration. DSC crystallinity and IR absorbance ratio, A 921 /A 956 ratio, showed no significant changes with degradation time for annealed PLLA films whereas as-cast PLLA film showed an increase in crystallinity with degradation; this revealed that degradation takes place predominantly in the free amorphous region of annealed PLLA films without changing long range and short range order V C