Colchicine resistance: Associated factors and its effect on <scp>health‐related</scp> quality of life in patients with familial Mediterranean fever

Gürsoy, Didem Erdem; Gezer, Halise Hande; Öz, N.; Özer, Aygün; Kasman, Sevtap Acer; Duruöz, Mehmet Tuncay

doi:10.1111/1756-185x.14407

Cited by 7 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reason is probably the more profound serosal inflammation in severe FMF. The frequency of chest pain is 35–60% in colchicine-resistant FMF patients in the literature, which may differ according to the ethnic group [ 7 , 8 , 15 , 17 , 24 ]; this frequency was 30% in our study. Another factor could be that chest pain is more frequent among patients with exon 10 mutations [ 25 , 26 ], and the majority of colchicine-resistant patients have exon 10 MEFV mutations.…”

Section: Discussionmentioning

confidence: 41%

“…Acute arthritis could occur during attacks, but also FMF patients more frequently have chronic arthritis [ 1 ]. Arthritis was observed in ≈30–50% of FMF patients who were colchicine resistant [ 7 , 17 , 24 ] and was present in 35% of colchicine-resistant patients in our cohort. In a recent study by Omma et al [ 24 ], the only significant difference between colchicine-resistant and colchicine-responsive FMF patients was the higher frequency of arthritis among colchicine-resistant patients.…”

Section: Discussionmentioning

confidence: 90%

“…Several studies have analysed the differences between colchicine-resistant and colchicine-responsive FMF patients [ 7–10 ]. Features such as early symptom onset, greater attack frequency, longer attack duration, erysipelas-like erythema (ELE), myalgia/protracted febrile myalgia, arthritis, higher colchicine dose, high acute phase reactants and homozygosity for exon 10 MEFV mutations have been associated with colchicine-resistance so far [ 7–10 ]. In one of these studies, the authors attempted to develop a predictive score for colchicine resistance in FMF patients, however, the number of patients was limited ( n = 104) [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A score for predicting colchicine resistance at the time of diagnosis in familial Mediterranean fever: data from the TURPAID registry

Batu,

Şener,

Arslanoglu Aydin

et al. 2023

Rheumatology

View full text Add to dashboard Cite

Objectives Colchicine forms the mainstay of treatment in familial Mediterranean fever (FMF). Around 5–10% of FMF patients are colchicine resistant and require anti-interleukin-1 drugs. We aimed to compare the characteristics of colchicine-resistant and colchicine-responsive patients and to develop a score for predicting colchicine resistance at the time of FMF diagnosis. Methods FMF patients (0–18 years) enrolled in the TURPAID (Turkish Pediatric Autoinflammatory Diseases) registry were included. The predictive score for colchicine resistance was developed by using univariate/multivariate regression and ROC analyses. Results A total of 3445 FMF patients (256 [7.4%] colchicine-resistant and 3189 colchicine-responsive) were included (F/M = 1.02; median age at diagnosis 67.4 months). Colchicine-resistant patients had longer, more frequent attacks and were younger at symptom onset and diagnosis (p< 0.05). Fever, erysipelas-like erythema, arthralgia, arthritis, myalgia, abdominal pain, diarrhea, chest pain, comorbidities, parental consanguinity, and homozygosity/compound heterozygosity for exon 10 MEFV mutations were significantly more prevalent among colchicine-resistant than colchicine-responsive patients (p< 0.05). Multivariate logistic regression analysis in the training cohort (n = 2684) showed that age at symptom onset, attack frequency, arthritis, chest pain, and having two exon 10 mutations were the strongest predictors of colchicine resistance. The score including these items had a sensitivity of 81.3% and a specificity of 49.1%. In the validation cohort (n = 671), its sensitivity was 93.5% and specificity was 53.8%. Conclusion We have developed a clinician-friendly and practical predictive score which could help us to identify FMF patients with a greater risk of colchicine resistance and tailor disease management individually at the time of diagnosis.

show abstract

Section: Discussionmentioning

confidence: 41%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A score for predicting colchicine resistance at the time of diagnosis in familial Mediterranean fever: data from the TURPAID registry

Batu,

Şener,

Arslanoglu Aydin

et al. 2023

Rheumatology

View full text Add to dashboard Cite

show abstract

“…In recent studies, colchicine has been found to have a substantial influence on morphological, biochemical and anatomical traits of different plants species which ultimately determine the effectiveness of their fluorescence and physiological activities [ 9 ]. However, it is highly toxic to human health and unsafe to the environment at elevated levels [ 10 ]. In plants, the elevated levels of colchicine also lead to deformities and diminish their growth and productivity [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the mechanism of transformation in Acacia nilotica (Linn.) triggered by colchicine seed treatment

Haider,

Nafees,

Iqbal

et al. 2024

BMC Plant Biol

View full text Add to dashboard Cite

Background Acacia nilotica Linn. is a widely distributed tree known for its applications in post-harvest and medicinal horticulture. However, its seed-based growth is relatively slow. Seed is a vital component for the propagation of A. nilotica due to its cost-effectiveness, genetic diversity, and ease of handling. Colchicine, commonly used for polyploidy induction in plants, may act as a pollutant at elevated levels. Its optimal concentration for Acacia nilotica's improved growth and development has not yet been determined, and the precise mechanism underlying this phenomenon has not been established. Therefore, this study investigated the impact of optimized colchicine (0.07%) seed treatment on A. nilotica's morphological, anatomical, physiological, fluorescent, and biochemical attributes under controlled conditions, comparing it with a control. Results Colchicine seed treatment significantly improved various plant attributes compared to control. This included increased shoot length (84.6%), root length (53.5%), shoot fresh weight (59.1%), root fresh weight (42.8%), shoot dry weight (51.5%), root dry weight (40%), fresh biomass (23.6%), stomatal size (35.9%), stomatal density (41.7%), stomatal index (51.2%), leaf thickness (11 times), leaf angle (2.4 times), photosynthetic rate (40%), water use efficiency (2.2 times), substomatal CO2 (36.6%), quantum yield of photosystem II (13.1%), proton flux (3.1 times), proton conductivity (2.3 times), linear electron flow (46.7%), enzymatic activities of catalase (25%), superoxide dismutase (33%), peroxidase (13.5%), and ascorbate peroxidase (28%), 2,2-diphenyl-1-picrylhydrazyl-radical scavenging activities(23%), total antioxidant capacity (59%), total phenolic (23%), and flavonoid content (37%) with less number of days to 80% germination (57.1%), transpiration rate (53.9%), stomatal conductance (67.1%), non-photochemical quenching (82.8%), non-regulatory energy dissipation (24.3%), and H2O2 (25%) and O−2 levels (30%). Conclusion These findings elucidate the intricate mechanism behind the morphological, anatomical, physiological, fluorescent, and biochemical transformative effects of colchicine seed treatment on Acacia nilotica Linn. and offer valuable insights for quick production of A. nilotica’s plants with modification and enhancement from seeds through an eco-friendly approach.

show abstract

“…Much research is available on creating, assessing, and applying health-related quality of life (HRQoL) metrics in public health. [1][2][3] Thus, the significance of life expectancy and HRQoL in the years before death has come to the attention of researchers and doctors worldwide. [1,4] For instance, there were significantly more publications in PubMed using the search term "HRQoL" from the medical subject headings between 1986 and 2021 (Fig.…”

Section: Introductionmentioning

confidence: 99%

A conceptual model of factors associated with health-related quality of life in men and women with knee osteoarthritis in Riyadh, Saudi Arabia: A multicenter cross-sectional study

et al. 2023

View full text Add to dashboard Cite

This study used a conceptual model to examine the factors influencing physical, mental, and overall health-related quality of life (HRQoL) in women and men aged 45 and older with knee osteoarthritis (KOA) in Saudi Arabia. In this multicenter cross-sectional study, we randomly included 356 individuals aged 45 years or above with doctor-confirmed KOA from the orthopedic and physiotherapy departments of the 5 tertiary hospitals in Riyadh, Saudi Arabia, between March 2016 and March 2017. We split all participants into men (n = 146) and women (n = 210) based on gender. A conceptual model was developed using the HRQoL influential potential factors, such as age, sex, education, occupation, and way of eating (sociodemographic), and clinical factors, such as osteoarthritis knee and its severity, duration, pain, and body mass index. The 36-item short form health survey and its subscales of the physical composite scale and mental composite scale were used to evaluate overall HRQoL, physical, and mental health, respectively. We used unadjusted multiple linear regression analyses to investigate the associations between gender-specific potential factors and HRQoL outcomes. Women and men aged between 60 and 64 years were more strongly associated significantly with less physical composite scale score by −3.17, (standard error [SE] = 1.71, P = .021) and −3.18 (SE = 1.69, P = .023) respectively, followed by the primary school or less education by −3.40 (SE = 1.27, P = .0002), severe KOA of −8.94 (SE = 0.99, P < .001), eating on the floor bending the knee of −3.93 (SE = 1.63, P = .042), and pain of −2.39 (SE = 0.26, P < .0001). Women and men with primary school or less education significantly had low mental composite scale and 36-item short form health survey scores of −3.07 (SE = 1.22, P = .041) and −3.23 (SE = 0.99, P = .018), respectively, followed by severe KOA of −4.07 (SE = 1.22, P = .001) and −6.50 (SE = 0.83, P < .0001) and eating on the floor, extending the knee at −3.35 (SE = 1.74, P = .043). Risk factors like age, education, pain, body mass index, and severe KOA are linked to poor physical, mental, and overall HRQoL among women and men in Saudi Arabia.

show abstract

Colchicine resistance: Associated factors and its effect on health‐related quality of life in patients with familial Mediterranean fever

Cited by 7 publications

References 31 publications

A score for predicting colchicine resistance at the time of diagnosis in familial Mediterranean fever: data from the TURPAID registry

A score for predicting colchicine resistance at the time of diagnosis in familial Mediterranean fever: data from the TURPAID registry

Exploring the mechanism of transformation in Acacia nilotica (Linn.) triggered by colchicine seed treatment

A conceptual model of factors associated with health-related quality of life in men and women with knee osteoarthritis in Riyadh, Saudi Arabia: A multicenter cross-sectional study

Contact Info

Product

Resources

About