Gender-related differences in disease activity and clinical features in patients with peripheral psoriatic arthritis: A multi-center study

Duruöz, Mehmet Tuncay; Gezer, Halise Hande; Nas, Kemal; Kılıç, Erdem; Sargın, Betül; Kasman, Sevtap Acer; Alkan, Hakan; Şahin, Nilay; Cengiz, Gizem; Cüzdan, Nihan; Gezer, İlknur Albayrak; Keskin, Dilek; Mülkoğlu, Cevriye; Reşorlu, Hatice; Ataman, Şebnem; Bal, Amanjit; Küçükakkaş, Okan; Yurdakul, Ozan Volkan; Melikoğlu, Meltem Alkan; Baykul, Merve; Ayhan, Fi̇kri̇ye Fi̇gen; Bodur, Hatice; Çalış, Mustafa; Çapkın, Erhan; Devrimsel, Gül; Gök, Kevser; Hizmetli, Sami; Kamanlı, Ayhan; Keskin, Yaşar; Ecesoy, Hilal; Kutluk, Öznur; Şen, Nesrin; Şendur, Ömer Faruk; Tekeoğlu, İbrahim; Tolu, Sena; Toprak, Murat; Tuncer, Tiraje

doi:10.1016/j.jbspin.2021.105177

Cited by 32 publications

(16 citation statements)

References 33 publications

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“…Contrary to our hypothesis, male, but not female, sex contributed to impaired psoriasis-related QoL. Results in the scientific literature on the role of sex differences in psoriasis-related QoL are somewhat contradictory, with some studies showing no sex differences ( 21 , 42 ), some reporting lower QoL for females in comparison to males ( 43 , 44 ), and some suggesting the opposite ( 45 ). However, in our study sample, we had more males than females (21.5 vs. 10.3%) who were not receiving treatment for psoriasis, and more males than females (13.8 vs. 4.3%) who were living alone during the COVID-19 pandemic.…”

Section: Discussioncontrasting

confidence: 99%

Factors associated with worsened clinical symptoms of psoriasis and disease-related quality of life during the COVID-19 lockdown: A cross-sectional study

et al. 2023

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ObjectiveIn this cross-sectional study, we aimed to evaluate the factors associated with psoriasis symptom worsening and impaired quality of life (QoL) in individuals with psoriasis during the COVID-19 pandemic lockdown.MethodsDuring the second COVID-19 national lockdown (January–April 2021) in Lithuania, individuals diagnosed with psoriasis were invited to fill in an anonymous online survey including sociodemographic and life-style factors, psoriasis-related clinical symptoms, the Dermatology Life Quality Index (DLQI) and the Patients' Health Questionnaire (PHQ).ResultsA total of 297 respondents completed the survey. The majority of them (52.5%) reported worsened clinical symptoms of psoriasis during the COVID-19 lockdown period. In total, 43.1% of responders reported significant depressive symptoms (PHQ-9 ≥ 10) and 23.6% reported impaired disease-related QoL (DLQI > 10). The strongest predictor of psoriasis symptoms worsening was the need for changes in psoriasis treatment, with an odds ratio (OR) of 2.73 (95% CI 1.37–5.44, p = 0.004) and decreased income (OR = 2.33, 95% CI 1.30–4.17, p = 0.004). The strongest predictor of impaired QoL was male sex (OR = 3.35, 95% CI 1.70–6.59, p < 0.001). Contribution of specific depressive symptoms was evident for both models.ConclusionWorsening of psoriasis symptoms during the COVID-19 lockdown was associated with decreased income, psoriasis treatment changes and depression symptoms. Impaired QoL was associated with male sex, symptom worsening and depression. Specific depression symptoms may have contributed to more symptom worsening and impaired QoL than the depressive symptomatology as a whole.

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Section: Discussioncontrasting

confidence: 99%

Factors associated with worsened clinical symptoms of psoriasis and disease-related quality of life during the COVID-19 lockdown: A cross-sectional study

et al. 2023

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“…These findings were in line with literature data and not unexpected [46,54]. Female gender had previously been found to be a predictor of UC patients reported fatigued [11,48,55]. In some past studies, IBD related surgery were related to fatigue [11,56].…”

Section: Discussionsupporting

confidence: 91%

Prevalence and factors associated with fatigue in patients with ulcerative colitis in China: a cross-sectional study

Yang

et al. 2022

BMC Gastroenterol

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Background Fatigue is one of the most common symptoms reported by patients with ulcerative colitis (UC), while it has not been fully recognized and taken seriously in clinical practice. We aimed to investigate the prevalence of fatigue in patients with UC and identify the factors associated with fatigue and its severity in China. Methods A cross-sectional study was conducted in Affiliated Hospital of Nanjing University of Chinese Medicine from May 2020 to February 2021. Demographic and clinical characteristics were collected. Fatigue was evaluated with the Fatigue Severity Scale and the Multidimensional Fatigue Inventory. The Hospital Anxiety and Depression Scale, the Pittsburgh Sleep Index Scale and the Malnutrition Universal Screening Tool were respectively used to evaluate the anxiety, depression, sleep disturbance and nutritional risk of patients with UC. Results A total of 220 UC patients were enrolled in this study. The prevalence of fatigue in patients was 61.8%, of which in patients with disease activity was 68.2%, and in patients in remission was 40.0%. Univariate analysis indicated that the Montreal classification, disease activity, anemia, anxiety, depression, sleep disturbance and high nutritional risk were the factors associated with fatigue in Patients with UC. Multivariate logistic regression analysis showed that the Montreal classification (E3: E1, OR = 2.665, 95% CI = 1.134–6.216), disease activity (OR = 2.157, 95% CI = 1.055–4.410) and anxiety (OR = 2.867, 95% CI = 1.154–7.126) were related to an increased risk of fatigue. Disease activity (RC = 0.240, 95% CI = 0.193–0.674) and anxiety (RC = 0.181, 95% CI = 0.000–0.151) were associated with severity of fatigue. Conclusions This study demonstrated that the prevalence of fatigue among UC patients in China. The Montreal classification, disease activity and anxiety are associated with an increased risk of fatigue.

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“…Duruöz (61) assessed a cohort of 1,038 psoriatic arthritis patients (678 females and 360 males) and found that females showed higher disease activity scores, in terms of "Disease Activity Score 28" (DAS28) and "clinical Disease Activity Index for Psoriatic Arthritis" (cDAPSA), with males reporting higher remission rates. "Minimal Disease Activity" (MDA) exhibited sex-specific differences too, favoring male patients.…”

Section: Clinical Radiological and Laboratory Sex-specific Differencesmentioning

confidence: 99%

Sex-Based Medicine Meets Psoriatic Arthritis: Lessons Learned and to Learn

et al. 2022

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Humorally associated autoimmune diseases generally show a female predominance whereas ankylosing spondylitis, a disease that overlaps with psoriatic arthritis (PsA), shows a male predominance. The present review ascertains the current knowledge of sex-specific differences related to psoriatic arthritis (PsA), a chronic, inflammatory condition associated with psoriasis. Sex differences may have important implications for clinical research in PsA and in terms of epidemiology (incidence, prevalence, lifetime risk, survival, and mortality), clinical, radiological, and laboratory features, and response to treatment. While nationwide surveys and large-scale databases and registries show no sex-specific differences, varying male/female ratios have been reported, ranging from 0.42 to 2.75 (comparable with those reported for psoriasis vulgaris: ranging from 0.28 to 2.38). This may reflect subtle, complex, nonlinear interactions between the biological make-up of the individual (genetic and epigenetic differences), hormonal components including menopausal status, environmental exposures including skeletal physical stressing, and psychological variables. There exists methodological heterogeneity and paucity of data concerning sex-specific differences, in terms of the specific population studied, study design, and the diagnostic criteria utilized. Harmonizing and reconciling these discrepancies would be of crucial importance in achieving the ambitious goals of personalized/individualized medicine and further standardized meta-data and Big Data could help disentangle and elucidate the precise mechanisms of underlying potential PsA sex-specific differences.

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Gender-related differences in disease activity and clinical features in patients with peripheral psoriatic arthritis: A multi-center study

Cited by 32 publications

References 33 publications

Factors associated with worsened clinical symptoms of psoriasis and disease-related quality of life during the COVID-19 lockdown: A cross-sectional study

Factors associated with worsened clinical symptoms of psoriasis and disease-related quality of life during the COVID-19 lockdown: A cross-sectional study

Prevalence and factors associated with fatigue in patients with ulcerative colitis in China: a cross-sectional study

Sex-Based Medicine Meets Psoriatic Arthritis: Lessons Learned and to Learn

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