123I-BMIPP delayed scintigraphic imaging in patients with chronic heart failure

Abstract

These data suggest that 123I-BMIPP uptake of delayed H/M enhances the image of CHF severity. The myocardial WR of 123I-BMIPP also effectively depicted the severity of CHF.

Metabolic Planar Imaging Using ¹²³I-<i>β</i>-Methyl-Iodophenyl Pentadecanoic Acid Identifies Myocardial Ischemic Memory After Intracoronary Acetylcholine Provocation Tests in Patients With Vasospastic Angina

“…Some investigators have noted that an increased WR of 123 I-BMIPP identifi es cardiac disease. [12][13][14]28,29) The severities of the H/M ratios and WR were associated with LVEF but BNP, respectively the present study. Delayed H/M ratios and WR of 123 I-BMIPP correlate with LVEF and BNP in patients with chronic heart failure.…”

“…We believe that what appears to be a reduced H/M ratio or increased WR can be more simply explained by the planar Thallium images. 27) Delayed H/M ratios are considered useful for assessing the disordered myocardium in several heart diseases 12,13) and might accurately refl ect impaired fatty acid metabolism. Some investigators have noted that an increased WR of 123 I-BMIPP identifi es cardiac disease.…”

“…[12][13][14] Regional tracer uptake was assessed using a 5-point scoring system (0, normal; 1, slightly reduced; 2, mildly reduced; 3, severely reduced; 4, no uptake) on the early and delayed SPECT images. 15) The left ventricular myocardium was divided into 17 segments corresponding to the vascular territories of the 3 major coronary arteries.…”

“…Global myocardial fatty acid metabolism assessed by 123 I-BMIPP using planar imaging is useful, and the severity of myocardial dysfunction is accurately reflected in the delayed heart-to-mediastinum (H/M) ratio in patients with heart disease. 12,13) However, whether or not planar 123 I-BMIPP imaging can accurately detect disrupted fatty acid metabolism in patients with VSA has not been fully evaluated. The present study attempted to determine whether or not 123 I-BMIPP-planar imaging can detect abnormal fatty acid metabolism after ischemic attack caused by coronary artery spasm.…”

Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy

“…In addition, it has no direct relationship with Annals of Nuclear Cardiology J-STAGE Advance published date: August 23, 2017 doi: 10.17996/anc. [17][18][19][20][21][22][23][24][25][26][27][28] plasma TG levels, because regulatory mechanism and responsible enzymes are different intracellularly from those in plasma (7). The probands for TGCV carried genetic mutations in the adipose triglyceride lipase (ATGL), which is the ratelimiting enzyme for hydrolysis of intracellular TG (8).…”