123I MIBG Appearance of Severe Renal Artery Stenosis

Jordan, Alistair; Seltzer, Marc; Siegel, Alan

doi:10.1097/rlu.0000000000000510

Cited by 8 publications

(2 citation statements)

References 6 publications

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“…123 I-MIBG uptake supposedly visualizes reinnervation over time in heart transplant patients [ 21 ], and renal tracer activity has been demonstrated in patients with severe renal artery stenosis or renal artery compression [ 22 , 23 ]. A study of renal 123 I-MIBG scintigraphy performed in 12 kidney transplant recipients has shown an association between time from transplantation and renal 123 I-MIBG uptake parameters, suggesting functional re-innervation [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

et al. 2020

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Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123 Metaiodobenzylguanidine (123I-MIBG) might provide information on renal sympathetic nervous activity. Renal transplantation induces complete denervation of the kidney and as such represents an ideal model to evaluate the renal 123I-MIBG scintigraphy method. The aim of this study was to evaluate whether renal 123I-MIBG scintigraphy can detect changes in renal sympathetic nervous activity following renal transplantation. Renal 123I-MIBG scintigraphy was performed in eleven renal transplant recipients at 1, 3, and 6 months following transplantation and in their respective living donors prior to their kidney donation. Relative uptake as well as washout was obtained. In transplanted patients, the relative 4 h uptake of 123I-MIBG, as measured by the kidney/background ratio, was 2.7 (0.4) (mean (SD)), 2.7 (0.5), and 2.5 (0.4) at 1, 3, and 6 months post-transplantation, respectively, as compared with the 4.0 (0.4) value in the donor kidney before donor nephrectomy (p < 0.01). There was no significant change in washout-rate between pre-transplantation and any of the follow-up time points. Living donor kidney transplantation was at 6 months post transplantation, associated with an almost 40% reduction in the relative 4 h 123I-MIBG uptake of the kidney. Further studies will help to fully establish its implications as a marker of renal innervation or denervation.

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Section: Introductionmentioning

confidence: 99%

Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

et al. 2020

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“…131 I-MIBG scintigraphy has been conventionally used to detect neural crest cell-derived tumors. 1,2 Diffusely increased MIBG uptake in a kidney due to RAS [3][4][5][6] or external compression of renal artery by a tumor 7 has been described only in a few cases in the literature. A unique feature of this case is demonstration of hemodynamic significance of RAS by a positive losartan renal scintigraphy that has not been shown in other similar cases.…”

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confidence: 99%

Unusual Renal Uptake of 131I-MIBG in a Young Hypertensive With Renal Artery Stenosis

Roopal,

Gaurav

2024

Clin Nucl Med

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A 10-year-old hypertensive girl underwent 131I-MIBG scan to rule out neural crest derived tumor. The whole-body images revealed diffuse intense tracer uptake in the right kidney, which persisted in 96-hour images as well. CT renal angiography revealed 90% to 95% right renal artery stenosis. Thereafter, she underwent baseline and angiotensin receptor blockade renal dynamic imaging, which revealed hemodynamically significant renal artery stenosis. Pattern of diffuse and intense 131I-MIBG uptake, albeit rare, still warrants further evaluation to rule out renal artery stenosis and investigate its hemodynamic significance for appropriate management.

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