128 Some derivatives of 1,3-diazaadamantane strongly stimulate strand exchange reaction between short oligonucleotides

Gabrielian, Anna; Bocharova, T. N.; Alexander, Elena A. Smirnova; Volodin, Alexander M.; Harutjunyan, Amalya; Gevorkyan, K. A.; Harutjunyan, Gayane

doi:10.1080/07391102.2013.786370

Cited by 7 publications

(3 citation statements)

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“…The affinity of both 1,3-diazaadamantanes to DNA increases at pH 6.5, the association constants of 5,7-dialkyl-substituted diazaadamantanes with DNA become close to each other (1400 and 500 M –1 , respectively). Thus, diazaadamantanes ( 130 ) and ( 131 ) demonstrated pH-dependent affinity to DNA [ 54 , 55 ].…”

Section: Interaction Of Azaadamantanes With Dna Enzymes and Receptorsmentioning

confidence: 99%

Azaadamantanes, a New Promising Scaffold for Medical Chemistry

et al. 2021

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Azaadamantanes are nitrogen-containing analogs of adamantane, which contain one or more nitrogen atoms instead of carbon atoms. This substitution leads to several specific chemical and physical properties. The azaadamantane derivatives have less lipophilicity compared to their adamantane analogs, which affects both their interaction with biological targets and bioavailability. The significant increase in the number of publications during the last decade (2009–2020) concerning the study of reactivity and biological activity of azaadamantanes and their derivatives indicates a great theoretical and practical interest in these compounds. Compounds with pronounced biological activity have been already discovered among azaadamantane derivatives. The review is devoted to the biological activity of azaadamantanes and their derivatives. It presents the main methods for the synthesis of di- and triazaadamantanes and summarizes the accumulated data on studying the biological activity of these compounds. The prospects for the use of azaadamantanes in medical chemistry and pharmacology are discussed.

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Section: Interaction Of Azaadamantanes With Dna Enzymes and Receptorsmentioning

confidence: 99%

Azaadamantanes, a New Promising Scaffold for Medical Chemistry

et al. 2021

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“…Owing to the presence of two ternary nitrogen atoms in the backbone of the 1,3-diazaadamantanes, these conjugates of inert adamantine acquire a chemical activity and an ability to be isolated in a water-soluble hydrochloride form. As we reported earlier, among a number of characterized 1,3-diazaadamantane derivatives that stimulate DNA Strand Exchange Reaction (SER), the compound HG122 appeared to be most promising for further study (Gabrielian et al, 2013;Mamaeva et al, 2014). Here we present the results of the SER titration via an excess of competing oligonucleotide, according to (Reynaldo, Vologodskij, Neri, & Lyamichev, 2000).…”

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confidence: 94%

137 Influence of 1,3-diazaadamantane derivative on the strand exchange between short oligonucleotides

Gabrielian

Bocharova

Smirnova

et al. 2015

Journal of Biomolecular Structure and Dynamics

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“…for further study (Gabrielian et al, 2013;Mamaeva et al, 2014). Here we present the results of the SER titration via an excess of competing oligonucleotide, according to (Reynaldo, Vologodskij, Neri, & Lyamichev, 2000).…”

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confidence: 99%