131I Induced Hematological Alterations in Rat Blood: Protection by Zinc

Abstract

The present study was planned to determine the potential of zinc in attenuating the toxicity induced by 131I in rat blood. Female wistar rats were segregated into four main groups. Animals in Group I served as normal controls; Group II animals were administered a dose of 3.7 Mbq of 131I (carrier free) intraperitoneally, Group III was supplemented with Zinc in the form of ZnSo4.7H2O (227 mg/l drinking water), and Group IV was given a combined treatment of Zinc as well as 131I, in a similar way as was given to Groups IV and II animals, respectively. The effects of different treatments were studied on various parameters in rat blood including hemoglobin (Hb) levels, % hematocrit, zinc protoporphyrins (ZPP), activities of enzymes which included aminolevulinic acid dehydratase (delta-ALAD) and Na+ K+ ATPase and uptake of 65Zn in blood. The study revealed an increase in the levels of hemoglobin, % hematocrit, activities of delta-ALAD, Na+ K+ ATPase and uptake of 65Zn, 7 days after the 131I treatment. On the contrary, the levels of ZPP were found to be significantly decreased after 131I treatment. However, zinc treatment to 131I-treated animals significantly attenuated the various biochemical and hematological indices. Moreover, zinc treatment to the 131I-treated animals could significantly decrease the uptake of 65Zn, which was increased after 131I treatment. Based upon these data, the present study suggests that zinc has the potential to attenuate 131I induced toxicity by restoring the altered hematological indices and biochemical changes.

Altered Uptake and Biological Half-Lives of 65Zn on Arsenic Exposure—Modulation by Zinc Treatment

“…The present study reveals that the liver has the maximum affinity for zinc, as evidenced by increased uptake of 65 Zn as compared with other organs; the same has also been shown in earlier studies [29]. Since liver is the major organ for the metabolic processes, therefore, zinc, after being absorbed from intestines, gets collected in the liver and then is distributed to various organs [30].…”

“…Additive supplementation of Zn in diet reduces the absorption of the metals from the gastrointestinal tract [27,28], hence protecting against metal toxicity. Concurrent zinc exposure can reduce the toxic effects of 131 I toxicity in blood [29].…”

The Effects of Zinc Treatment on the Blood–Brain Barrier Permeability and Brain Element Levels During Convulsions

“…P6500) group: rats treated with PTZ (80 mg/kg, i.v.) to induce epileptic seizures, (3) Zn group: rats treated with ZnCl 2 227 ml/kg [17] added to drinking water for 2 months, and (4) Zn + PTZ group. Cannulations of the femoral artery and vein were performed in animals.…”