2001
DOI: 10.1006/mben.2001.0187
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13C Metabolic Flux Analysis

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Cited by 734 publications
(676 citation statements)
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“…5) shed additional light on the metabolic pathways used by E. coli during the anaerobic nongrowth phase. Normally, 13 C labeling experiments are conducted to provide information for stoichiometric metabolic flux analysis (23,29). In a metabolic flux analysis experiment, a metabolic and isotopic steady state should be achieved using either a chemostat or a well-controlled fed batch (23).…”
Section: Vol 73 2007mentioning
confidence: 99%
“…5) shed additional light on the metabolic pathways used by E. coli during the anaerobic nongrowth phase. Normally, 13 C labeling experiments are conducted to provide information for stoichiometric metabolic flux analysis (23,29). In a metabolic flux analysis experiment, a metabolic and isotopic steady state should be achieved using either a chemostat or a well-controlled fed batch (23).…”
Section: Vol 73 2007mentioning
confidence: 99%
“…Estimation of the flux profiles using information from metabolomics analysis. Estimation can also be based on hypotheses about desirable flux distributions in an engineered pathway [8,9,19].…”
Section: Optimization and Risk Analysis Of Complex Living Entities (Omentioning
confidence: 99%
“…A large amount of effort has been invested in the quantification of the metabolic fluxes within cells, using methods such as metabolic flux analysis [8][9][10]. However, one of the limitations of these methods is that they provide only a snapshot of the fluxes and do not quantify the responses of metabolic networks to the changes in the metabolic parameters or the process parameters, such as oxygen and carbon substrate limitation, or stress agents, such as organic acids and pH.…”
mentioning
confidence: 99%
“…In addition, both measurement effort/time and potential to resolve fluxes are not the same for all measurement candidates. For example, external fluxes are considered to be easier to measure than isotopic distributions (Wiechert, 2001). This implies that the measurements must be carefully selected so as to eliminate any ambiguity in computing the remaining fluxes at a relative minimum of cost.…”
Section: Application To Mfamentioning
confidence: 99%