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Pérez-López, Marcos; Anglade, Patricia; Bec-Ferté, M.P.; Debrauwer, Laurent; Perdu, Elisabeth; Cravedi, J.P.; Rouimi, Patrick

doi:10.1023/a:1007885332573

Cited by 30 publications

(1 citation statement)

References 52 publications

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“…In the dataset that consists of the 1% highly expressed genes in the South African sardine liver transcriptome ( Supplementary Table S3), genes such as glutathione S-transferase (GTS) are a well-studied family of liver enzymes that play a critical role in the detoxification of electrophilic toxins [37]. High expression levels for these genes have been reported from both healthy liver cells and hepatic cells after exposure to toxic substances in different fish species, such as plaice (Pleuronectes platessa), flounder (Platichthys flesus), big-belly seahorse (Hippocampus abdominalis), and grass carp (Ctenopharyngodon idella) [38][39][40][41][42][43][44].…”

Section: Resultsmentioning

confidence: 99%

Transcriptomic Diversity in the Livers of South African Sardines Participating in the Annual Sardine Run

Emami‐Khoyi

Roux

Adair

et al. 2021

Genes

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During austral winter, the southern and eastern coastlines of South Africa witness one of the largest animal migrations on the planet, the KwaZulu-Natal sardine run. Hundreds of millions of temperate sardines, Sardinops sagax, form large shoals that migrate north-east towards the subtropical Indian Ocean. Recent studies have highlighted the role that genetic and environmental factors play in sardine run formation. In the present study, we used massively parallel sequencing to assemble and annotate the first reference transcriptome from the liver cells of South African sardines, and to investigate the functional content and transcriptomic diversity. A total of 1,310,530 transcripts with an N50 of 1578 bp were assembled de novo. Several genes and core biochemical pathways that modulate energy production, energy storage, digestion, secretory processes, immune responses, signaling, regulatory processes, and detoxification were identified. The functional content of the liver transcriptome from six individuals that participated in the 2019 sardine run demonstrated heterogeneous levels of variation. Data presented in the current study provide new insights into the complex function of the liver transcriptome in South African sardines.

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Section: Resultsmentioning

confidence: 99%

Transcriptomic Diversity in the Livers of South African Sardines Participating in the Annual Sardine Run

Emami‐Khoyi

Roux

Adair

et al. 2021

Genes

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Olfaction in Aquatic Vertebrates

Tierney

2015

Handbook of Olfaction and Gustation

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Marine Glutathione S-Transferases

2007

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The aquatic environment is generally affected by the presence of environmental xenobiotic compounds. One of the major xenobiotic detoxifying enzymes is glutathione S-transferase (GST), which belongs to a family of multifunctional enzymes involved in catalyzing nucleophilic attack of the sulfur atom of glutathione (gamma-glutamyl-cysteinylglycine) to an electrophilic group on metabolic products or xenobiotic compounds. Because of the unique nature of the aquatic environment and the possible pollution therein, the biochemical evolution in terms of the nature of GSTs could by uniquely expressed. The full complement of GSTs has not been studied in marine organisms, as very few aquatic GSTs have been fully characterized. The focus of this article is to present an overview of the GST superfamily and their critical role in the survival of organisms in the marine environment, emphasizing the critical roles of GSTs in the detoxification of marine organisms and the unique characteristics of their GSTs compared to those from non-marine organisms.

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Cited by 30 publications

References 52 publications

Transcriptomic Diversity in the Livers of South African Sardines Participating in the Annual Sardine Run

Transcriptomic Diversity in the Livers of South African Sardines Participating in the Annual Sardine Run

Olfaction in Aquatic Vertebrates

Marine Glutathione S-Transferases

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