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Ondruš, D; Horňák, M; Breza, J; Matoŝka, J; Schnorrer, M; Белан, В. Н.; Kausitz, J

doi:10.1023/a:1014466110566

Cited by 22 publications

(7 citation statements)

References 7 publications

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“…HD chemotherapy was not an option in this case due to a necrotic, superinfected and bleeding tumor bulk. For patients initially ineligible for surgery because of an advanced and acutely life-threatening disease, primary chemotherapy is the favored therapy [ 6 , 7 ]. In this case, hospitalization occurred due to fever, thrombosis of deep leg veins, bilateral acute pulmonary embolism and tumor bleeding leading to ICU treatment.…”

Section: Discussionmentioning

confidence: 99%

Primary Chemotherapy in a 47-Year-Old Patient with Giant Ulcerative and Necrotizing Nonseminomatous Testicular Germ Cell Tumor

et al. 2021

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Testicular cancer is a rare disease; however, cure rates are high for all tumor stages. Mostly, the disease is diagnosed in an early (local) stage. We report the case of a 47-year-old male patient with a giant nonseminomatous germ cell tumor. At the time of diagnosis, the patient demonstrated a necrotizing and ulcerating growing mass in the left scrotum with an approximate size of 22 × 18 cm. According to the prognostic classification of the International Germ Cell Cancer Collaborative Group (IGCCCG 1997), the patient exhibited a high-risk profile due to alpha-fetoprotein >10,000 ng/mL and lactate dehydrogenase >10× the upper limit of normal in serum. Primary orchiectomy was infeasible due to the tumor’s size, the patient’s poor general condition and initial intensive care unit treatment. Primary systemic chemotherapy was applied. After 3 cycles of cisplatin, etoposide and bleomycin, along with 1 cycle of cisplatin, etoposide and ifosfamide, tumor resection with histomorphological examination showed a complete pathological response. Despite the delayed initiation of the therapy, primary chemotherapy was completed timely and showed promising results. Reasons for the late hospitalization were personal responsibilities regarding his family. Better awareness and knowledge of testicular cancer among young men might prevent the here reported delay of medical consultation and avoid testicular tumors of such enormous size. Psychosocial assessment and distress management is important as an integral part of comprehensive care of testicular cancer patients.

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Section: Discussionmentioning

confidence: 99%

Primary Chemotherapy in a 47-Year-Old Patient with Giant Ulcerative and Necrotizing Nonseminomatous Testicular Germ Cell Tumor

et al. 2021

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“…Benefit of this therapeutic approach is the immediate management of acute abdominal and/or pulmonary symptoms of life-threatening distant metastases in super high risk patients [9]. Another advantage of this approach is the possibility of surgical treatment of residual metastatic masses simultaneously with orchiectomy [10]. However, sanctuary sites such as testis are poorly penetrated by these pharmacologic agents.…”

Section: Discussionmentioning

confidence: 99%

Complete Remission by Primary Chemotherapy of Advanced Non-Seminomatous Germ Cell Tumor in an Intra-Abdominal Testis

Sarkis¹,

Kourié²,

Gharios³

et al. 2014

OJU

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Ectopic testis predisposes to a high risk of germ cell tumor development. Treatment of advanced testicular germ cell tumor developing in an uncorrected abdominal testis is based on primary chemotherapy followed by removal of the testis along with residual masses. However, persistence of viable tumor particularly in the testis is always noted since testis penetration of chemotherapeutic agents is reduced. We report a case of complete pathological remission of a patient with advanced non-seminomatous germ cell tumor in intra-abdominal testis by primary chemotherapy alone, with a review of the literature.

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“…Rates of remnant viable tumour vary from under 10% to just under 40% in the literature (table 4) [2,3,4,5,6,7,8,9]. Additionally mature teratoma has been found in 25-50% of specimens.…”

Section: Discussionmentioning

confidence: 99%

Orchidectomy after Primary Chemotherapy for Metastatic Testicular Cancer

Ramsey¹,

Kerr

Howard

et al. 2013

Urol Int

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Objective: To examine the outcome of orchidectomy following primary chemotherapy in patients with metastatic testicular cancer. Patients and Methods: This was a retrospective analysis of patients who underwent primary chemotherapy without initial orchidectomy for testicular cancer between 1982 and 2006. The patients were identified from the regional oncology cancer database in our tertiary referral hospital. Their case notes were reviewed regarding initial presentation, chemotherapy, clinical progress and pathological outcomes following surgery. Results: 21 evaluable patients were identified (14 non-seminomatous germ cell tumours, 7 seminomas). 16 patients underwent standard orchidectomy within 12 months of commencing chemotherapy and 5 patients underwent significantly delayed orchidectomy (19-68 months, mean 45.1 months). Orchidectomy in the standard group showed tumour necrosis or a scar in 13 patients (81%) and differentiated or mature teratoma in 3 patients associated with bulky poorly responsive retroperitoneal disease (19%). In the delayed orchidectomy group 3 out of 5 patients had viable seminoma, of which two were associated with carcinoma in situ. Conclusion: Our study raises concerns as regards a potentially high risk of late tumour development in testes which are preserved following apparent tumour resolution after chemotherapy.

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Cited by 22 publications

References 7 publications

Primary Chemotherapy in a 47-Year-Old Patient with Giant Ulcerative and Necrotizing Nonseminomatous Testicular Germ Cell Tumor

Primary Chemotherapy in a 47-Year-Old Patient with Giant Ulcerative and Necrotizing Nonseminomatous Testicular Germ Cell Tumor

Complete Remission by Primary Chemotherapy of Advanced Non-Seminomatous Germ Cell Tumor in an Intra-Abdominal Testis

Orchidectomy after Primary Chemotherapy for Metastatic Testicular Cancer

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