15-Acetylthioxy-furodysinin lactone, a potent LTB4 receptor partial agonist from a marine sponge of the genus

Carté, Brad; Mong, Seymour; Poehland, B.; Sarau, Henry M.; Westley, John; Faulkner, D. John

doi:10.1016/s0040-4039(00)99108-1

Cited by 18 publications

(13 citation statements)

References 5 publications

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“…This result strongly suggested to explore other bioassay target for compound 1 including antibiotic as some furanosesquiterpene metabolites were reported to show promising bioactivity (Richou et al, 1989). The bioactivity of compound 1 has never been reported, however related derivative such as acetylthioxy-furodysinin lactone, a bioactive component of the marine sponge Dysidea, was reported to show as a potent LTB4 receptor partial agonist (Carte' et al, 1989).…”

Section: The Chemistry Of Hypselodoris Infucatamentioning

confidence: 99%

BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucata

Mudianta

Martiningsih²,

Prasetia³

et al. 2016

Indonesian J. Pharm.

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Marine organisms, in particular nudibranchs (Mollusca: nudibranchia), are known as a rich source of chemically diverse secondary metabolites exhibiting potential as antimalarial, antiinflammatory, antiviral and anticancer activity. We presented the chemical investigation of an extract of nudibranch Hypselodoris infucata collected from Bali, an unexplored water but rich in nudibranch diversity. The extract contained the known (-)furodysinin (1), a furanosesquiterpene that for the first time isolated from this species. Metabolite 1 was purified by chromatography and the structure was characterised by comparison of 1 H NMR data with that of the reported data. The absolute configuration was determined by comparing the optical rotation values with the known enantiomer. In vitro cytotoxic activity of compound 1 against HeLa cell line displayed an IC50 at 102.7µg/mL. We also report for the first time the development of a method to assay nudibranch extracts for their feeding deterrence activity against local shrimps Penaeus vannamei. The extract show food rejection with highly significant difference in respect to the control (P = 0.0061) at natural concentration of 3.0mg/mL.

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Section: The Chemistry Of Hypselodoris Infucatamentioning

confidence: 99%

BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucata

Mudianta

Martiningsih²,

Prasetia³

et al. 2016

Indonesian J. Pharm.

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“…(Carte et al, 1989) receptor-mediated signal transduction processes related to LTB 4 . Thus, it will likely be of use in studying the role of leukotrienes in inflammation (Moog et al, 1990).…”

Section: Anti-inflammatory/analgesic Compoundsmentioning

confidence: 99%